解放军医学杂志2024，Vol.49Issue(6)：636-642,7.DOI:10.11855/j.issn.0577-7402.2641.2024.0110
阻塞性睡眠呼吸暂停与高血压:一项双向孟德尔随机化研究
Obstructive sleep apnea and hypertension:a bidirectional Mendelian randomization study
摘要
Abstract
Objective To investigate the causal relationship between obstructive sleep apnea(OSA)and hypertension using bidirectional Mendelian randomization(MR).Methods Genetic data for OSA were obtained from the Genome-wide association study(GWAS)of FinnGen Biobank,including 16 761 cases and 201 194 controls,from which 5 single-nucleotide polymorphisms(SNPs)were screened as instrumental variables(IVs)for OSA.Genetic data for hypertension were obtained from GWAS of UK Biobank,including 124 227 cases and 337 653 controls from which 214 SNPs were selected as IVs for hypertension.Multiple MR methods,mainly Inverse variance weighted(IVW),were used for analysis.Sensitivity analysis of MR results was performed using MR-Egger regression et al,and IVs were evaluated using F values.Results OSA was associated with an increased risk of hypertension(OR=1.053,95%CI 1.019-1.089,P<0.01),and hypertension was significantly associated with the risk of developing OSA(OR=1.812,95%CI 1.354-2.425,P<0.001).Heterogeneity was observed in both two-way outcomes(OSA→ hypertension,P<0.001;hypertension→ OSA,P<0.001),but no evidence of horizontal pleiotropy was detected(OSA→ hypertension,P=0.666;hypertension→ OSA,P=0.556).The IVs selected in this study were strong instrumental variables for both OSA and hypertension(OSA-IVs F=14.695;hypertension-IVs F=39.624).Conclusions Our findings indicate a bidirectional causal relationship between OSA and hypertension,with a particularly significant effect of hypertension on the development of OSA.关键词
阻塞性睡眠呼吸暂停/高血压/孟德尔随机化/双向/因果关系Key words
obstructive sleep apnea/hypertension/Mendelian randomization/bidirectional/causality分类
医药卫生引用本文复制引用
夏露,谢治年,廖芯艺,张启星,李镇圻..阻塞性睡眠呼吸暂停与高血压:一项双向孟德尔随机化研究[J].解放军医学杂志,2024,49(6):636-642,7.基金项目
This work was supported by the Scientific Research Foundation of Yunnan Provincial Department of Education(2022Y863) 云南省教育厅研究生项目(2022Y863) （2022Y863）
