解放军医学杂志2024，Vol.49Issue(6)：711-717,7.DOI:10.11855/j.issn.0577-7402.0481.2024.0325
TGR5在心血管疾病中的作用研究进展
Research progress on the role of TGR5 in cardiovascular diseases
摘要
Abstract
Takeda G protein-coupled receptor 5(TGR5)is a bile acid receptor located on the surface of cell membrane,widely distributed in many tissues and cells in the body,and can be directly activated by most bile acids in vivo.TGR5 plays an important role in various physiological and pathophysiological processes,including cellular Ca2+transport,oxidative stress,cell proliferation,inflammatory responses,and mitochondrial metabolism,thereby maintaining mitochondrial homeostasis and vascular endothelial function,and inhibiting the progression of cardiovascular diseases such as atherosclerosis,myocardial hypertrophy,and cardiac remodeling after myocardial infarction.Currently,with the gradual clinical application of numerous bile acid and bile acid derivatives drugs,it is necessary to further investigate the role of TGR5 in the cardiovascular system,which is an important basis for clinical application of these new drugs.This review discusses the relationship between TGR5 and cardiovascular system from five perspectives:TGR5's involvement in regulating macrophages,endothelial function,vascular smooth muscle cells,cardiomyocytes,and mitochondrial metabolism.It summarizes the recent research progress,aiming to provide the theoretical basis for TGR5 as a novel therapeutic target for cardiovascular diseases.关键词
武田G蛋白偶联受体5/心血管疾病/动脉粥样硬化/胆汁酸Key words
Takeda G protein coupled receptor 5/cardiovascular diseases/atherosclerosis/bile acid分类
医药卫生引用本文复制引用
杨曦,孙雄山,罗涵,胡陶,张黎,王嘉,王强..TGR5在心血管疾病中的作用研究进展[J].解放军医学杂志,2024,49(6):711-717,7.基金项目
This work was supported by the National Natural Science Foundation of China(82100419),the Sichuan Natural Science Foundation(2022NSFSC0820),and the Project of General Hospital of Western Theater Command(2021-XZYG-B28) 国家自然科学基金(82100419) （82100419）
四川省自然科学基金(2022NSFSC0820) （2022NSFSC0820）
西部战区总医院院管课题(2021-XZYG-B28) （2021-XZYG-B28）
