解放军医学杂志2024，Vol.49Issue(6)：726-732,7.DOI:10.11855.j.issn.0577-7402.1239.2024.0124
M1/M2型巨噬细胞在肝纤维化中的作用研究进展
Research progress on the role of M1/M2 macrophages in hepatic fibrosis
摘要
Abstract
Hepatic fibrosis refers to repeated or persistent inflammation and necrosis of liver parenchymal cells and excessive deposition of liver fibrous connective tissue caused by various etiologies,which is a necessary stage for chronic liver disease to develop into cirrhosis.Etiological treatment as antiviral therapy can reduce the inflammation of the liver tissues to a certain degree,but cannot completely stop the process of liver fibrosis.In recent years,researchers have found that intrahepatic macrophages play an important role in the occurrence and progression of hepatic fibrosis,among which M1/M2 macrophages have become the key to exploring macrophages to regulate hepatic fibrosis.This article will focus on the role and mechanism of intrahepatic M1/M2 macrophages in hepatic fibrosis.关键词
肝纤维化/巨噬细胞/细胞外基质Key words
hepatic/liver fibrosis/macrophages/extracellular matrix分类
医药卫生引用本文复制引用
杨钰萌,王新,麻婧..M1/M2型巨噬细胞在肝纤维化中的作用研究进展[J].解放军医学杂志,2024,49(6):726-732,7.基金项目
This work was supported by the Key Clinical Research Project of Air Force Military Medical University(2021LC2114) 空军军医大学临床研究重点项目(2021LC2114) （2021LC2114）
