老年医学与保健2024，Vol.30Issue(3)：823-829,7.
基于孟德尔随机化分析方法探求肌酐与椎间盘退行性疾病的相关性
An analysis based on the Mendelian randomization method exploring the correlation between creatinine and degenerative inter-vertebral disc disease
摘要
Abstract
Objective Utilizing the Mendelian randomization model to explore the impact of creatinine levels on Degen-erative intervertebral disc disease.Methods Using bidirectional Mendelian randomization,this section evaluates the correla-tion between creatinine levels and Degenerative intervertebral disc disease.This study employed two independent public genetic databases from Genome-Wide Association Studies(GWAS),this study primarily evaluates the causal relationship using the re-sults of the Inverse-variance weighted method in Mendelian randomization analysis,with four additional methods serving as ref-erences.CochransQ test for heterogeneity,Mendelian randomization Egger-intercept test,and Mendelian randomization-PRES-SO method employed for detecting heterogeneity and pleiotropy;Leave-one-out analysis and sensitivity,with forest plots and fun-nel plots utilized for sensitivity detection;Radial-Mendelian randomization approach used for outlier detection.Results Creati-nine levels showed a significant positive causal effect on Degenerative intervertebral disc disease[IVW:OR=1.218;95％CI:(1.085,1.368);P=0.001,＜0.05].Degenerative intervertebral disc disease has no causal effect on creatinine levels[IVW:OR=0.961;95％CI:(0.923,1.001);P=0.055,＞0.05].Heterogeneity tests indicated no significant bias(P=0.081＞0.05),and Pleiotropy tests showed a low level of bias(P=0.471,＞0.05).Conclusion Elevated creatinine levels are a potential risk factor for degenerative intervertebral disc disease.关键词
椎间盘退行性疾病/肌酐/孟德尔随机化Key words
degenerative intervertebral disc disease/creatinine/mendelian randomization引用本文复制引用
禹到均,孙铮铮,苟海昕..基于孟德尔随机化分析方法探求肌酐与椎间盘退行性疾病的相关性[J].老年医学与保健,2024,30(3):823-829,7.基金项目
上海市科委资助项目(18401901700) （18401901700）
上海市卫健委资助项目[ZY(2018-2020)-ZYJS-19] （2018-2020）
