临床眼科杂志2024，Vol.32Issue(3)：284-287,4.DOI:10.3969/j.issn.1006-8422.2024.03.021
他汀类药物治疗对2型糖尿病视网膜病变影响的研究进展
Research progress of statin therapy on type 2 diabetes retinopathy
李雪雪 1张真稳2
作者信息
- 1. 116004 大连医科大学
- 2. 225001 扬州大学临床医学院
- 折叠
摘要
Abstract
The incidence rate of diabetes in China is increasing year by year,and its complications will continue to rise in the future.The retina is the most metabolically active tissue in the body and is therefore easily affected by diabe-tes.Sustained hyperglycemia damages the microvasculature of the retina resulting in hemodynamic changes,thickening of the basement membrane,loss of pericytes,and blood-retinalbarier(BRB)dysfunction.Diabetes retinopathy is a microvas-cular complication of diabetes,affecting about 35%of diabetes patients.It is a global epidemic in the 21st century and a major cause of blindness among the elderly in developed countries.It is urgent to delay its progress.Statins are famous for their role in lowering blood cholesterol,and are widely used in patients with cardiovascular and metabolic diseases.They have different effects on different pathophysiological pathways involving angiogenesis,inflammation,apoptosis and antioxi-dation,resulting in new treatment options.Some studies have shown that the use of statins can slow down the progress of diabetes retinopathy(DR).Therefore,this article reviews the relationship between statins and diabetes retinopathy,focus-ing on the potential role of statins in treatment.关键词
2型糖尿病/他汀类药物/糖尿病视网膜病变/综述Key words
Type 2 diabetes/Statins/Diabetes retinopathy/Review引用本文复制引用
李雪雪,张真稳..他汀类药物治疗对2型糖尿病视网膜病变影响的研究进展[J].临床眼科杂志,2024,32(3):284-287,4.
