昆明医科大学学报2024，Vol.45Issue(6)：57-68,12.DOI:10.12259/j.issn.2095-610X.S20240608
ANGPT1和TEK影响人类肿瘤进展的泛癌分析
Pan-Cancer Analysis for the Effects of ANGPT1 and TEK on Human Tumor Progression
摘要
Abstract
Objective To probe the expression level,prognostic value,and immune invasion of angipoietin-1(ANGPT1)and its receptor tyrosine kinase(TEK)in pan-cancer.Methods TIMER2.0、Kaplan-Meier plotter and UALCAN etc.databases were used to analyze the expression,prognostic value of ANGPT1 and TEK in various types of tumors.SangerBox 3.0 and R software were used to analyze the relationship between ANGPT1 and TEK tumor mutational burden(TMB),microsatellite instability(MSI),immune checkpoint(ICP)and immune cell infiltration.String database,GO and KEGG analysis were used to identify proteins and regulatory pathways related to ANGPT1 and TEK.Results ANGPT1 and TEK showed low expression in most tumors(P<0.05).Patients with low expression of ANGPT1 and TEK had a worse prognosis(P<0.05).The expression levels of ANGPT1 and TEK were correlated with the clinical stages of clear cell renal carcinoma,bladder urothelial carcinoma,and invasive breast carcinoma(P<0.05).The expression of ANGPT1 and TEK was significantly correlated with TMB,MSI and ICP in various tumors(P<0.05),and was significantly positively correlated with immune invasion(P<0.05).The genes were closely related to ANGPT1 and TEK include GRB2,PIK3R1,EGFR,etc.,which were mainly involved in a series of biological processes and functions related to Grb2-EGFR,ERBB3:ERBB2,Shc-EGFR and other complexes,mainly involved ErbB signaling pathway.Conclusion ANGPT1 and TEK may play an important role in tumorigenesis and development through the ErbB signaling pathway,and are expected to be potential clinical prognostic markers for various types of cancer.关键词
ANGPT1/TEK/泛癌分析/R语言Key words
ANGPT1/TEK/Pan-cancer analysis/The R Programming Language分类
医药卫生引用本文复制引用
杜国庆,刘志琴,李姚,史永华..ANGPT1和TEK影响人类肿瘤进展的泛癌分析[J].昆明医科大学学报,2024,45(6):57-68,12.基金项目
新疆地区高发疾病教育部重点实验室基金资助项目(2023A02) （2023A02）
