昆明医科大学学报2024，Vol.45Issue(6)：100-105,6.DOI:10.12259/j.issn.2095-610X.S20240613
Stanford A型主动脉夹层的个体化血流数值模拟
Individualized Numerical Simulation of Blood Flow in Stanford Type A Aortic Dissection
摘要
Abstract
Objective To investigate the hemodynamic changes after the occurrence of Stanford type A aortic dissection.Methods Computed tomography angiography(CTA)images of the aorta were collected from 4 Stanford A type aortic dissection patients and 2 healthy volunteers,and the three-dimensional models of the aorta were established and meshed.The above models were numerically simulated by fluid simulation software.Results The blood flow in the aorta of healthy volunteers was approximately laminar.The blood flow field in the true lumen was approximately laminar.Turbulence not only occurred near the intimal tear of the true lumen,but also near the area where the false lumen compressed the true lumen.The wall pressure of the true lumen was higher than that of the false lumen.During the systolic phase,the peak wall pressure of the false lumen was located at the primary entry tear of the dissection,the high wall shear stress appeared around the true lumen compressed by false lumen and the tear of false lumen.Moreover,stress concentration occurred at the intimal tear.Compared to aortic dissection with a single tear,aortic dissection with two tears exhibited lower wall shear stress around the intimal tear.Conclusion In-dividualized computational fluid dynamics analysis can provide reference for personalized diagnosis and treatment of aortic dissection.关键词
计算流体力学/血流动力学/数值模拟/主动脉夹层Key words
Computational fluid dynamics/Hemodynamics/Numerical simulation/Aortic dissection分类
医药卫生引用本文复制引用
于振坤,刘康,林华,王蓓蓓,张洪明,夏健明..Stanford A型主动脉夹层的个体化血流数值模拟[J].昆明医科大学学报,2024,45(6):100-105,6.基金项目
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202001AY070001-282) （202001AY070001-282）
心血管疾病国家重点实验室开放课题(2019kfyf-01) （2019kfyf-01）
云南省临床医学中心项目(2020YFKT-12) （2020YFKT-12）
国家重点研发计划(no.022YFC2503400),云南省心血管病临床研究中心(202302AA310045) （no.022YFC2503400）
云南省教育厅科学研究基金资助项目(2021J0227) （2021J0227）
