昆明医科大学学报2024，Vol.45Issue(6)：154-160,7.DOI:10.12259/j.issn.2095-610X.S20240621
环泊酚联合瑞芬太尼在腔镜胃癌根治术麻醉中的有效性与安全性
Effectiveness and Safety Analysis of Cyclopol Combined with Remifentanil in Anesthesia for Endoscopic Gastric Cancer Radical Surgery
摘要
Abstract
Objective To investigate the effectiveness and safety of cyclophenol combined with remifentanil in anesthesia for laparoscopic radical gastrectomy for gastric cancer.Methods A total of 100 patients who underwent laparoscopic radical gastrectomy for gastric cancer admitted to 900 Hospital of the Joint Logistic Support Force from August 2022 to July 2023 were randomly divided into two groups:the propofol combined with remifentanil group(50 cases)received propofol combined with remifentanil anesthesia,and the cyclopol combined with remifentanil group(50 cases)received cyclophenol combined with remifentanil anesthesia.The vital signs(respiratory rate,heart rate,and blood oxygen saturation)of the two groups of patients were observed.Anesthesia indicators(onset time of anesthesia,recovery time of spontaneous breathing,awakening time,time of leaving the room),anesthesia effect,and adverse reactions(Injection pain,hypotension,hypoxemia,respiratory depression,dizziness,drowsiness)were also observed.Results The interaction effect of respiratory rate between two groups,time points,and between groups/time points showed no statistically significant difference(P>0.05);The interaction between heart rate and blood oxygen saturation between two groups,time points,and between groups and time points showed statistically significant differences(P<0.05).There was no statistically significant difference(P>0.05)in the respiratory rate between the two groups of T0 to T5.The heart rate of T1 and T2 in the combination of propofol and remifentanil group was higher than that in the combination of propofol and remifentanil group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in heart rate between the two groups at other times(P>0.05).The blood oxygen saturation of T2 in the combination of propofol and remifentanil group was higher than that in the combination of propofol and remifentanil group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in blood oxygen saturation between the two groups at other times(P>0.05).There was no statistically significant difference in the onset time of anesthesia between the two groups(P>0.05).The spontaneous breathing recovery time,awakening time,and departure time of the group treated with propofol combined with remifentanil were shorter than those of the group treated with propofol combined with remifentanil,and the differences were statistically significant(P<0.05).The total effective rate of the combination of propofol and remifentanil group was 96.00%,which was higher than the 84.00%of the combination of propofol and remifentanil group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the combination of propofol and remifentanil group was 10.00%,which was lower than the 28.00%in the combination of propofol and remifentanil group,and the difference was statistically significant(P<0.05).Conclusion The application of cyclophorol combined with remifentanil in anesthesia for laparoscopic radical gastrectomy for gastric cancer has a good effect,can stabilize the patient's intraoperative vital signs,improve anesthesia indicators,reduce adverse reactions,and can be promoted.关键词
环泊酚/瑞芬太尼/腔镜胃癌根治术/麻醉/有效性/安全性Key words
Cyclophenol/Remifentanil/Endoscopic radical gastrectomy for gastric cancer/Anesthesia/Effectiveness/Security分类
医药卫生引用本文复制引用
王克棪,林冰婷,翁晓琳,黄滨,王烈..环泊酚联合瑞芬太尼在腔镜胃癌根治术麻醉中的有效性与安全性[J].昆明医科大学学报,2024,45(6):154-160,7.基金项目
福建省自然科学基金资助项目(2020J011138) （2020J011138）
