匹诺塞林通过抑制自噬减轻慢性间歇性缺氧诱导的BEAS-2B细胞损伤OACSTPCD
Pinocembrin alleviates BEAS-2B cell damage induced by chronic intermittent hypoxia through inhibiting autophagy
目的:探讨匹诺塞林(pinocembrin,PIN)对慢性间歇性缺氧(chronic intermittent hypoxia,CIH)诱导的BEAS-2B人支气管上皮细胞损伤的影响及可能的调控机制.方法:培养BEAS-2B细胞,通过细胞计数试剂8(cell counting kit 8,CCK8)确定最适CIH干预时长和最适PIN处理浓度,将BEAS-2B细胞分为对照组(CON组)、CIH组、CIH+PIN组3组.通过CCK8检测不同处理组BE…查看全部>>
Objective To investigate the effect of pinocembrin(PIN)on BEAS-2B human bronchial epithelial cell injury induced by chronic intermittent hypoxia(CIH)and its possible regulatory mechanism.Methods The optimal CIH intervention duration and PIN treatment concentration were determined by cell counting kit 8(CCK8)in BEAS-2B cells.BEAS-2B cells were divided into control group(CON group),CIH group and CIH+PIN group.The proliferation activity of BEAS-2B cells in diff…查看全部>>
何嫣婕;何美娟;王韵;朱春雪;黄汉鹏
江苏大学附属医院呼吸与危重症医学科,江苏 镇江 212000江苏大学附属医院呼吸与危重症医学科,江苏 镇江 212000江苏大学附属医院呼吸与危重症医学科,江苏 镇江 212000江苏大学附属医院呼吸与危重症医学科,江苏 镇江 212000江苏大学附属医院呼吸与危重症医学科,江苏 镇江 212000
临床医学
匹诺塞林慢性间歇性缺氧自噬凋亡
PinocembrinChronic intermittent hypoxiaAutophagyApoptosis
《内科理论与实践》 2024 (2)
115-120,6
江苏省科技项目(BE2021694)镇江"金山英才"高层次领军人才培养计划项目(YLJ202105)
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