宁夏大学学报（自然科学版）2024，Vol.45Issue(2)：186-195,10.
肿瘤代谢重编程为胶质瘤治疗提供新靶点研究
Tumor Metabolism Reprogramming Provides Novel Targets for Glioblastoma Therapy
摘要
Abstract
Glioma research has witnessed significant progress in recent decades,yet effective treatments for glio-blastoma remain elusive,leading to dismal prognoses for patients.Metabolic reprogramming stands out as a cru-cial hallmark of gliomas.With advancements in metabolic technologies,novel mechanisms of intracellular meta-bolic dysregulation,influenced by glioma gene mutations and metabolic microenvironmental control,are unveiled.These encompass alterations in glucose,lipid,and amino acid metabolism.Targeting metabolic path-ways regulated by genetic mutations has emerged as a promising avenue for selectively eradicating glioma cells.Several potential therapeutic agents are currently under investigation,demonstrating remarkable efficacy in in vivo models.This review provides a comprehensive overview of recent advances in understanding the mecha-nisms of metabolic abnormalities in gliomas and the advancements in targeted drug therapies for this challenging disease.关键词
胶质瘤/肿瘤代谢重编程/靶向治疗/胶质母细胞瘤Key words
glioma/tumor metabolism reprogramming/targeted therapy/glioblastoma分类
医药卫生引用本文复制引用
何智钧,毛优翔,江鹏..肿瘤代谢重编程为胶质瘤治疗提供新靶点研究[J].宁夏大学学报（自然科学版）,2024,45(2):186-195,10.基金项目
国家自然科学基金面上项目(82372824) （82372824）
中国博士后科学基金资助项目(BX20220175) （BX20220175）
