首都师范大学学报（自然科学版）2024，Vol.45Issue(3)：64-73,10.DOI:10.19789/j.1004-9398.2024.03.006
催化反应增强痕量肿瘤标志物电化学检测性能研究进展
Progress in enhancing the electrochemical detection performance of trace tumor markers based on catalytic reactions
摘要
Abstract
Sensitive detection of tumor markers is one of the most important safeguards for early diagnosis of cancer,selection of therapeutic strategies and prognostic monitoring.The content of tumor markers in serum is low,usually existing at trace level,and even very few other tumor markers are only on the order of femtograms or picograms per millilitre of serum,and subtle changes in their concentrations are indicative of tumor occurrence,progression and therapeutic efficacy.It is of great clinical significance and has received extensive attention how to achieve sensitive detection of small concentration changes of tumor markers at trace level.Because of its high sensitivity,fast response,easy operation,and miniaturization of the instrument,electrochemical immunosensors have received much attention and made great progress in the study of detecting small concentration changes of tumor markers at trace level.This paper reviews the progress made in catalytic reactions to enhance the performance of electrochemical detection of tumor markers,with special focus on the application of bioenzymes,nano-enzymes,and the use of electrochemical metal catalysts,and also provides an outlook on the problems to be solved.关键词
肿瘤标志物/电化学传感器/催化反应/生物酶/纳米酶/电化学金属催化剂Key words
tumor marker/electrochemical detection/catalytic reactions/bioenzymes/nanoenzymes/electrochemical metal catalysts分类
化学化工引用本文复制引用
李万超,马占芳..催化反应增强痕量肿瘤标志物电化学检测性能研究进展[J].首都师范大学学报（自然科学版）,2024,45(3):64-73,10.基金项目
国家自然科学基金面上项目(22172104) （22172104）
北京市教委-北京市自然科学基金联合资助重点项目(KZ202110028042) （KZ202110028042）
