首都师范大学学报（自然科学版）2024，Vol.45Issue(3)：74-86,13.DOI:10.19789/j.1004-9398.2024.03.007
基于可植入电极的活体脑化学电分析研究进展
Advancements of in vivo brain chemical electroanalysis based on implantable electrodes
摘要
Abstract
Implantable electrode-based in vivo electrochemical sensing research has consistently played a pivotal role in driving advancements in analytical methods within the field of neurochemical research.The intricacies of brain structures and the real-time nature of various physiological activities impose rigorous demands on analytical approaches.High specificity,elevated sensitivity,robust interference resistance,and favorable biocompatibility are essential prerequisites for in situ analysis in living systems.With the development of novel functional materials and advancements in electrochemical research methodologies,there has been significant progress in the field of in vivo electrochemical analysis employing implantable electrodes.Nonetheless,this field continues to encounter a series of challenges.This article reviews the current applications of implantable electrodes,such as enzyme-modified electrodes,aptamer-modified electrodes,ion-selective electrodes,liquid-liquid interface-based electrodes,and ion current rectifying electrodes in the field of in vivo electrochemical sensing,as well as the major progress in the research of their key properties such as biocompatibility and sensitivity.The intention is to offer valuable insights for future research in precision detection within the intricate environment of the brain.关键词
活体电化学传感/可植入电极/脑神经化学/活体原位分析Key words
in vivo electrochemical sensors/implantable electrodes/neurochemistry of the brain/in vivo analysis分类
化学化工引用本文复制引用
孔凡镇,何瑞煜,顾超越,林雨青..基于可植入电极的活体脑化学电分析研究进展[J].首都师范大学学报（自然科学版）,2024,45(3):74-86,13.基金项目
国家自然科学基金项目(22104095,22074095,22374103) （22104095,22074095,22374103）
北京市自然科学基金面上项目(2222005) （2222005）
