绝经后女性肌少症与颈动脉斑块发生风险的关系OA北大核心CSTPCD

Objective:To investigate the relationship between sarcopenia and the risk of carotid plaque in postmenopausal women.Methods:A total of 527 postmenopausal women who underwent physical examination in the health examination center of Huadong Sanatorium from March to October 2022 were selected as the research objects by random cluster sampling.The body composition analyzer(InBody720)was used to calculate the skeletal muscle mass of human limbs,appendicular skeletal muscle index(ASMI)was calculated and handgrip and walking speed were measured.Clinical data were collected,univariate combined with multivariate regression analysis was used to explore the relationship between sarcopenia and the risk of carotid plaque in postmenopausal women,and receiver operating characteristic(ROC)curve was used to explore the diagnostic value of ASMI in the occurrence of carotid plaque in postmenopausal women.Results:Among 527 postmenopausal women,172(32.6%)had carotid plaque.In postmenopausal women,ASMI in the carotid plaque group was significantly lower than that in the non-carotid plate group[5.42(4.88,6.09)kg/m2 vs 6.63(5.73,7.78)kg/m2,P<0.001].The incidence of sarcopenia in the carotid plaque group was significantly higher than that in the non-carotid plaque group(45.3%vs 18.0%,P<0.001).The lower the ASMI value in postmenopausal women,the higher the risk of carotid plaque(Pfor trend<0.001).Multivariate logistic regression analysis showed that postmenopausal women with sarcopenia significantly increased the risk of carotid plaque(OR=3.486,95%CI 2.237-5.432).ROC showed that ASMI had a higher predictive value for carotid plaque than waist circumference and body mass index(AUC=0.756).Conclusions:Sarcopenia significantly increases the risk of carotid artery plaque in postmenopausal women,and ASMI can be used as a simple predictor of carotid artery plaque.