实用医学杂志2024，Vol.40Issue(13)：1864-1868,1873,6.DOI:10.3969/j.issn.1006-5725.2024.13.017
脑脊液联合血常规检测在多发性脑胶质瘤与原发性中枢神经系统淋巴瘤鉴别诊断中的临床价值
Clinical value of joint detection of cerebrospinal fluid and blood routine indicators in differentiating between multiple gliomas and primary central nervous system lymphoma
摘要
Abstract
Objective To investigate the clinical significance of combined cerebrospinal fluid(CSF)and routine blood parameter analysis in differentiating between multiple cerebral glioma(MCG)and primary central nervous system lymphoma(PCNSL).Methods We Rretrospectively analyzed the clinical data,CSF and routine blood indicators levels of 62 MCG patients and 56 PCNSL patients admitted to Beijing Tiantan Hospital,Capital Medical University from November 2017 to March 2023.Additionally,we assessed the diagnostic value of individual meaningful indicators as well as their combinations in distinguishing between MCG and PCNSL.Results The levels of CSF total cell count,CSF white cell count,CSF:pro,lactate,routine bloodperipheral neutrophil count,and neu-trophil percentage were significantly higher in the MCG group than in the PCNSL group(P<0.05);while the levels of CSF:Glu,CSF:cl,routine blood lymphocyte count,eosinophil,lymphocyte percentage,and eosinophil percent-age were significantly higher in the PCNSL group than in the MCG group(P<0.05).The AUCs of CSF cell count,CSF white cell count,CSF:pro,lactate,routine blood neutrophil count,neutrophil percentage for differentiating MCG from PCNSL were 0.900,0.899,0.797,0.867,0.828 and 0.772 respectively;sensitivities were 72.4%,77.6%,63.8%,67.2%,72.4%,82.8%,77.6%and 81%,with sensitivities of 97.1%,100%,88.2%,91.2%,88.2%,64.7%,100%and 94.1%,respectively.In addition,the combined detection of CSF total cell count,CSF white cell count,CSF:pro,routine blood neutrophil count and neutrophil percentage in CSF had an AUC of 0.919 for differentiating MCG from PCNSL,with a sensitivity and specificity of 77.6%and 100%,respectively.Conclusions Combined detection of CSF indicators including CSF total cell count,CSF white cell count,CSF:pro,along with routine blood markers such as neutrophil count and neutrophil percentage,holds significant clinical utility for differ-entiating between MCG and PCNSL.关键词
多发性脑胶质瘤/原发性中枢神经系统淋巴瘤/脑脊液/血常规/鉴别诊断Key words
multiple cerebral glioma/primary central nervous system lymphoma/cerebrospinal fluid/routine blood/differential diagnosis分类
医药卫生引用本文复制引用
姜华,赵晖,张丽敏,王丹,韩平,孙越红,李玉文,张晨曦,姜文灿,李虓..脑脊液联合血常规检测在多发性脑胶质瘤与原发性中枢神经系统淋巴瘤鉴别诊断中的临床价值[J].实用医学杂志,2024,40(13):1864-1868,1873,6.基金项目
北京市科学技术协会青年人才托举工程(编号:BYESS2022170) （编号:BYESS2022170）
首都医科大学"本科生科研创新"项目(编号:XSKY2023298) （编号:XSKY2023298）
