实用医学杂志2024，Vol.40Issue(13)：1869-1873,5.DOI:10.3969/j.issn.1006-5725.2024.13.018
人类免疫缺陷病毒相关肺动脉高压患者的肺动脉管径特征及联合肿瘤坏死因子-α的诊断价值
Research on the diagnostic value of pulmonary artery diameter characteristics and combined TNF-α in patients with HIV associated pulmonary hypertension
摘要
Abstract
Objective To investigate the characteristics of pulmonary artery diameter in patients with human immunodeficiency virus(HIV)infection-associated pulmonary hypertension(PAH),and to explore the clinical significance of pulmonary artery diameter correlation indices combined with tumor necrosis factor-α(TNF-α)for early screening and diagnosis of HIV-associated pulmonary hypertension,aiming to provide valuable clinical insights.Methods A retrospective analysis was conducted on 65 HIV-infected patients admitted to the Eighth Hospital Affiliated to Guangzhou Medical University between May 2017 and December 2023.Based on echocardiog-raphy findings,the patients were categorized into an observation group(23 cases with PAH)and a control group(42 cases without PAH).Measurements of pulmonary artery diameter(PA),distal pulmonary artery diameter(dPA),and aortic diameter were obtained in both groups,and the ratio of dPA to aortic diameter(rPA)was cal-culated.Additionally,serum TNF-α levels were recorded.The clinical significance of each index in early screening and diagnosis of HIV-related pulmonary hypertension was analyzed.Results The PA,dPA,rPA,and TNF-α levels in the observation group were significantly higher compared to those in the control group.Pearson linear correlation analysis revealed a significant positive correlation between TNF-α and both dPA and rPA.Two-column correlation analysis demonstrated a significant association between HIV-PAH and PA,dPA,rPA,as well as TNF-α(P<0.05).The combined measurement of serum TNF-α with dPA and rPA exhibited an area under the curve(AUC)of 0.891 for diagnosing HIV-APAH,with a sensitivity of 0.870 and specificity of 0.881.Conclusion The combination of pulmonary artery diameter and TNF-α provides a more accurate indication of the presence of HIV-PAH,enabling early screening,follow-up,or intervention in high-risk patients.This finding holds significant implications for enhancing patient prognosis.关键词
人类免疫缺陷病毒病/肺动脉高压/肺动脉管径/肿瘤坏死因子-αKey words
humanimmunodeficiency virus/pulmonary hypertension/artery diameter/tumor necrosis factor-α分类
医药卫生引用本文复制引用
许庆元,袁伟锋,陈沐,莫晓能..人类免疫缺陷病毒相关肺动脉高压患者的肺动脉管径特征及联合肿瘤坏死因子-α的诊断价值[J].实用医学杂志,2024,40(13):1869-1873,5.基金项目
广州市科技计划项目(编号:2023A03J0784,2023A03J0785) （编号:2023A03J0784,2023A03J0785）
广州医科大学附属市八医院华英科研基金项目(编号:HY202301B01) （编号:HY202301B01）
