实用医学杂志2024，Vol.40Issue(13)：1895-1900,6.DOI:10.3969/j.issn.1006-5725.2024.13.023
T细胞耗竭与呼吸系统疾病关系的研究进展
Research progress in T cell exhaustion and its relationship with respiratory diseases
摘要
Abstract
T cell exhaustion occurs mostly in chronic infections,cancers and autoimmune diseases.Continuous antigenic stimulation leads to the generation of exhausted T cells,which is characterized by progressive loss of effector function,continuous high expression of inhibitory receptors,transcription and epigenetic changes,and metabolic disorders.The in-depth study of the specific mechanism of T cell exhaustion is providing new ideas for the immunotherapy of chronic infection,lung cancer and chronic airway inflammatory disease in respiratory dis-eases.This paper discussed the influencing factors and characteristics of T cell exhaustion and reviewed the current research status of T cell exhaustion and respiratory diseases.关键词
T细胞耗竭/抑制性受体/呼吸系统疾病/免疫治疗Key words
T cell exhaustion/inhibitory receptors/respiratory diseases/immunotherapy分类
医药卫生引用本文复制引用
丁紫琪,张倩..T细胞耗竭与呼吸系统疾病关系的研究进展[J].实用医学杂志,2024,40(13):1895-1900,6.基金项目
江苏省社会发展项目(编号:BE2020651) （编号:BE2020651）
江苏省第五期"333"高层次人才项目(编号:BRA2020015) （编号:BRA2020015）
常州市科技项目(编号:CE20205023) （编号:CE20205023）
