实用肝脏病杂志2024，Vol.27Issue(4)：527-530,4.DOI:10.3969/j.issn.1672-5069.2024.04.009
超重/肥胖非酒精性脂肪性肝病儿童磁共振质子密度脂肪分数检测意义研究
Magnetic resonance proton density fat fraction in overweight/obese children with nonalcoholic fatty liver disease
摘要
Abstract
Objective This study was conducted to investigate application of magnetic resonance proton density fat fraction(MRI-PDFF)in predicting nonalcoholic steatohepatitis(NASH)in overweight and obese children with nonalcoholic fatty liver disease(NAFLD).Methods 74 overweight and 28 obese children with NAFLD were enrolled in 903rd Hospital,Jiangyou,between December 2022 and December 2023,and all underwent liver biopsies for diagnosis of NASH.MRI-PDFF was obtained by MRI scan,liver stiffness measurement(LSM)and controlled attenuation parameter(CAP)were determined by Fibroscan and area under receiver operating characteristic(AUC)was applied to predict diagnostic performance.Results Of the 102 overweight/obese children,histo-pathological examination diagnose simple nonalcoholic fatty liver(SNFL)in 75 cases and NASH in 27 cases;basic mass index,serum ALT,AST,TG,MRI-PDFF,LSM and CAP in children with NASH were(32.2±3.4)kg/m2,(92.7±31.3)U/L,(96.8±34.1)U/L,(3.1±1.2)mmol/L,(12.5±4.7)%,(11.7±1.4)kPa and(370.4±146.9)dB/m,all significantly different compared to[(26.7±2.2)kg/m2,(38.2±4.4)U/L,(33.0±3.4)U/L,(2.3±0.7)mmol/L,(7.7±2.0)%,(6.2±1.0)kPa and(262.3±61.2)dB/m,respectively,P<0.05)]in those with SNFL;percentages of overweight and obese in children with NASH were 37.0%and 63.0%,much different compared to 85.3%and 14.7%in those with SNFL(P<0.05);ROC analysis showed that the AUC was 0.87(95%CI:0.80-0.93),with sensitivity(Se)of 81.5%and specificity(Sp)of 85.3%,when MRI-PDFF was 11.9%as the cut-off-value in predicting NASH,while the AUC was 0.81(95%CI:0.78-0.89),with Se of 85.2%and Sp of 58.7%(P<0.05),when LSM was 10.8 kPa and CAP was 310.5dB/m combination as the cut-off-value.Conclusion The diagnostic performance of MRI-PDFF in predicting NASH in overweight/obese children with NAFLD is satisfactory,and from the economic and convenient point of view,we recommend Fibroscan for screening.关键词
非酒精性脂肪性肝炎/磁共振质子密度脂肪分数/肝脏硬度检测/受控衰减参数/儿童/诊断Key words
Nonalcoholic steatohepatitis/Magnetic resonance imaging/Proton density fat fraction/Fibroscan/Children/Diagnosis引用本文复制引用
罗洪霞,李静秋,李媛媛,冯国隽,余霞..超重/肥胖非酒精性脂肪性肝病儿童磁共振质子密度脂肪分数检测意义研究[J].实用肝脏病杂志,2024,27(4):527-530,4.基金项目
四川省绵阳市卫健委科研基金资助项目(编号:20220074) （编号:20220074）
