摘要
Abstract
Objective To understand the occurrence of adverse drug reaction(ADR)of intravenous medication in hospitalized children in Luoyang Maternal and Child Health Hospital,analyze the characteristics of ADRs,and propose corresponding strategies to improve the safety of intravenous medication in children.Methods A retrospective analysis was conducted on the ADR reports of 87 hospitalized children received in Luoyang Maternal and Child Health Hospital from June 2022 to June 2023.All children had received intravenous medication treatment.The age,gender,primary disease,drug type,ADR occurrence time,organs and(or)systems involved in ADR,clinical manifestations,and outcomes of the children were statistically analyzed.Results Among the 87 hospitalized children,67.82%were male and 32.18%were female,with males being more than females,with a statistically significant difference(χ2=22.092,P＜0.05).Children under 1 year old accounted for a higher proportion than other age groups,with a statistically significant difference(χ2=30.456,P＜0.05).The primary diseases of the children were mainly respiratory system diseases,digestive system diseases,blood system diseases,etc.The types of intravenous medication were mainly anti-infective drugs,respiratory system drugs,hormone drugs,circulatory system drugs,etc.The proportion of respiratory system diseases was higher than other diseases,and the proportion of anti-infective drugs was higher than other types of drugs,with statistically significant differences(χ2=25.674,58.752,both P＜0.05).The ADR occurrence rate of medication from 1 to 72 hours was higher than within 1 hour and after 72 hours,with a statistically significant difference(χ2=41.379,P＜0.05).ADR involved multiple organs and systems such as skin and appendages,digestive system,circulatory system,respiratory system,etc.Among them,the ADR occurrence rate of skin and appendages and digestive system was higher than other systems,with a statistically significant difference(χ2=102.704,P＜0.05).Conclusion The ADR of intravenous medication in hospitalized children in our hospital is related to various factors and involves multiple organs or systems.Clinically,it is necessary to continue to strengthen the pharmaceutical management of intravenous treatment during the hospitalization of children,improve the rationality of medication,and thus prevent the occurrence of ADR.关键词
住院儿童/静脉用药/药物不良反应/药物类型/累及器官/临床表现Key words
hospitalized children/intravenous medication/adverse drug reaction/drug type/involved organ/clinical manifestation分类
医药卫生
