湖北科技学院学报（医学版）2024，Vol.38Issue(4)：306-312,7.DOI:10.16751/j.cnki.2095-4646.2024.04.0306
基于碳点印迹聚合物的荧光传感器对磺胺甲恶唑的超灵敏检测
Ultrasensitive Detection of Sulfamethoxazole by a Fluorescent Sensor Based on Carbon Dots Imprinted Polymers
摘要
Abstract
Objective To develope a novel fluorescence sensor for the detection of sulfamethoxazole(SMZ)in urine and blood samples.Carbon dots(CDs)embedded silica molecular imprinted polymer was synthesized and fabricated for the selective and ultrasensitive detection of SMZ.Methods The CDs has been synthesized by hydrothermal method by using citric acid and urea as carbon source.The surface of the CDs was covered with MIPs matrix(CDs@MIP)via sol-gel polymerization.In this progress,SMZ,3-aminopropyltriethoxysilane(APTES)and tetraethoxysilane(TEOS)were applied as a template,a functional monomer and a cross linker,respectively.The synthesized materials were characterized and tested by transmission electron microscopy(TEM),scanning electron microscope(SEM),fourier transform infrared spectrometry(FT-IR)and fluorometry.Results Under optimal ex-perimental conditions,the optical sensor had a linear range of 0-20 μg/mL with the detection limit down to 0.042μg/mL.This probe was successfully used for determination of SMZ in urine and blood samples.The recovery rate was between 86.2%-94.4%.Conclusion The fluorescence sensor based on CDs@MIP can identify SMZ ultrasensitively and the method is simple,rapid,highly selective and anti-interference,which make it suitable for the rapid determination of traces of SMZ in blood and urine samples.This method has a good practical value.关键词
磺胺甲恶唑/荧光传感器/碳点/分子印迹聚合物Key words
Sulfamethoxazole/Fluorescence sensor/Carbon dots/Molecularly imprinted polymers分类
医药卫生引用本文复制引用
支悦,袁莹莹,陈妃,陈涛,陈林枫..基于碳点印迹聚合物的荧光传感器对磺胺甲恶唑的超灵敏检测[J].湖北科技学院学报（医学版）,2024,38(4):306-312,7.基金项目
湖北省自然科学基金青年项目(2022CFB877) （2022CFB877）
湖北省教育厅科研计划项目(Q20222807) （Q20222807）
湖北科技学院博士启动项目(BK202215) （BK202215）
湖北科技学院科研创新团队项目(2022T03) （2022T03）
