中国骨伤2024，Vol.37Issue(6)：629-634,6.DOI:10.12200/j.issn.1003-0034.20230883
水凝胶在周围神经损伤修复领域的应用研究进展
Progress on application of hydrogels in the field of peripheral nerve injury repair
摘要
Abstract
As one of the common traumatic diseases in clinical practice,peripheral nerve injury(PIN)often causes nerve pain,abnormal reflexes,autonomic disorders,and even sensorimotor disorders due to the slow regeneration rate after injury,which seriously affects body function.Even as the gold standard of treatment,autologous nerve transplantation has limitations such as limited donor area and donor injury,which greatly limits its clinical application effect.Therefore,the preparation of ar-tificial nerve grafts suitable for clinical practice has become the future development trend of peripheral nerve injury treatment,and the repair of injury defects and the promotion of nerve regeneration have also become research hotspots in tissue engineer-ing and regenerative medicine.In recent years,extensive research has been carried out on nerve guidance conduits(NGCs)in the field of nerve regeneration and repair,in which scaffold materials and intemal fillers have also become the focus of research as the core elements of neural catheters,and a series of achievements have been made in the application of new materials,em-bedding stem cells/precursor cells,and developing trophic factors and drug-loaded sustained-release systems.Therefore,this paper focuses on the application progress of hydrogel and its related derivative materials in the field of peripheral nerve injury repair,and provides new ideas for promoting the related research of tissue engineering and clinical medicine.关键词
水凝胶/周围神经损伤/人工神经导管Key words
Hydrogel/Peripheral nerve injury/Artificial nerve conduit分类
医药卫生引用本文复制引用
秦春,孔令同,许硕贵..水凝胶在周围神经损伤修复领域的应用研究进展[J].中国骨伤,2024,37(6):629-634,6.基金项目
国家自然科学基金青年科学基金项目(编号:82302718)National Natural Science Foundation of China Youth Sci-ence Foundation(No.82302718) （编号:82302718）
