应用数学和力学2024，Vol.45Issue(6)：719-734,16.DOI:10.21656/1000-0887.450107
基质刚度和生长因子协同驱动上皮-间质转化的力-化耦合机制
The Mechanochemical Coupling Mechanism of Matrix Stiffnesses and Growth Factors Driving the Epithelial-Mesenchymal Transition
摘要
Abstract
The epithelial-mesenchymal transition(EMT)is a critical step in physiological and pathological processes such as the embryonic development,the wound healing,and the cancer progression,wherein cells transition from a tightly adherent epithelial state to a dispersed mesenchymal state.An EMT core circuit model driven by the synergistic regulation of matrix stiffnesses and growth factors was proposed.The results show that,during the EMT,the matrix stiffnesses and growth factors collaboratively regulate the expression of the E/N-cadherin,a typical cell-cell adhesion molecule,by modulating the EMT-activating transcription factors,thus influencing the progression and reversibility of the EMT.The model elucidates the mechanism of synergistic interactions between mechanical and chemical factors on cell-cell adhesion during the EMT,laying a theoretical foundation for understanding the occurrence,development mechanisms,and preventive strategies against dis-eases such as cancer.关键词
力学模型/力-化耦合/上皮-间质转化/细胞间力学黏附Key words
mechanical modeling/mechanochemical coupling/epithelial-mesenchymal transition/cell-cell adhesion分类
力学引用本文复制引用
朱鸿源,王与帅,林敏..基质刚度和生长因子协同驱动上皮-间质转化的力-化耦合机制[J].应用数学和力学,2024,45(6):719-734,16.基金项目
国家自然科学基金(12202345 （）
12372316) （）
中国博士后科学基金(2022M722534) （2022M722534）
中央高校基本科研业务费(xzy012024081) （xzy012024081）
