应用数学和力学2024，Vol.45Issue(6)：753-762,10.DOI:10.21656/1000-0887.450089
张力调控影响创口重塑的数值模拟研究
Numerical Simulation Study of Wound Remodeling Under Tension Regulation
摘要
Abstract
The tissue remodeling is widespread in human tissues and organs,closely associated with morpho-genesis,wound healing,fibrosis development,as well as cancer spread and metastasis.The mechanical micro-environment plays a crucial role in the tissue remodeling,yet the impact of tension regulation on wound remod-eling remains unclear.A dynamic mathematical model for tissue remodeling induced by active cell contraction was established.The processes of lateral and inner wound remodeling in tissues with different pretensions were simulated with the finite element method.Additionally,the effects of tension regulation on wound remodeling were studied based on the model.The results show that,the tension regulation significantly influences the wound remodeling process,an appropriate tension reduction would effectively decrease the stress magnitude and the wound size.This study contributes to a deeper understanding of the mechanical effects in tissue remod-eling and provides references for potential interventions in wound healing.关键词
组织重塑/伤口愈合/有限元方法/力学调控Key words
tissue remodeling/wound healing/finite element method/mechanical regulation分类
力学引用本文复制引用
蔡威,周子星,张作启,黄国友..张力调控影响创口重塑的数值模拟研究[J].应用数学和力学,2024,45(6):753-762,10.基金项目
国家自然科学基金(12272278) （12272278）
湖北省自然科学基金(2023AFB586) （2023AFB586）
中央高校基本科研业务费(2042023kf0167) （2042023kf0167）
