隔姜灸联合揿针对恶性肿瘤化疗患者胃肠道反应的影响OA北大核心CSTPCDMEDLINE

Objective To observe the efficacy and safety of ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation in the prevention and treatment of chemotherapy-induced nausea and vomiting(CINV)in patients with malignant tumors.Methods Patients with malignant tumors and suffering from chemotherapy were randomly divided into control group(35 cases,4 cases dropped off)and observation group(35 cases,2 cases dropped off).The patients of the control group were treated by orally taking ondansetron hydrochloride tablets 8 mg/time,3 times a day for 3 d,and those of the observation group treated by ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation of Zusanli(ST36),Neiguan(PC6),Tianshu(ST25),Zhongwan(CV12)and Guanyuan(CV4)once a day for a total of 3 d,based on the treatment of the control group.The patients'gastrointestinal reaction degree after the 1st,2nd and the 3rd day of treatment were recorded.The Karnofsky performance status(KPS)score(0-100 points)was used for assessing the patients'quality of life.The TCM syndrome score(4 grades:no,mild,medium and severe,i.e.0,2,4 and 6 points)was given according to the patients'severity of symptoms of spleen(stomach)qi deficiency(nausea and vomiting,abdominal distension after eating,belching,loss of appetite,weakness and laziness to speak,fatigue,and loose stool).The safety of the treatment was assessed by examining the patients'blood routine,liver function and kidney function,and the adverse reactions including blisters,allergies,burns and fainting during acupuncture treatment.Results After the 2nd and 3rd day of treatment,the patients conditions of vomiting and nausea in the observation group were significantly better than those of the control group(P<0.05).The TCM syndrome score and KPS score were significantly decreased in comparison with those of pre-treatment in both groups(P<0.05),and the TCM syndrome score was obviously lower in the observation group than in the control group(P<0.05).No significant differences were found between the two groups in the KPS score after the treatment,and in the levels of white blood cells(WBC),hemoglobin(HGB),platelets(PLT),absolute neutrophil count(ANC),alanine transaminase(ALT),aspartate aminotransferase(AST),creatinine(Cr),and blood urea nitrogen(BUN).Conclusion The use of ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation is safe for CINV patients,and can effectively relieve nausea and vomiting and alleviate digestive symptoms.