骨质疏松症病证结合动物模型的研究进展
Progress in the establishment and evaluation of osteoporosis disease and syndrome combination animal models
摘要
Abstract
With increased population aging,the incidence of osteoporosis(OP)increases year by year,and has become a key global public health problem.Its main characteristics are reduced bone mass and damage to bone microstructure,often clinically manifesting as pain,hunched-back posture,height reduction,and even bone fractures.Therefore,it is particularly important to actively carry out scientific research related to OP,and the construction of animal models has become one of the key drivers of medical research,especially for exploring new treatments and in drug development.Animal models that are a"combination of disease and syndrome",integrating the characteristics of Chinese medicine,occupy an irreplaceable position in research aiming to modernize traditional Chinese medicines.On the basis of the current research status of disease-syndrome combination OP animal models,this paper summarizes model construction and evaluation method to provide certain ideas and references for research using these specialized OP animal models.关键词
骨质疏松症/病证结合/动物模型/研究进展Key words
osteoporosis/combination of disease and syndrome/animal models/research progress分类
生物科学引用本文复制引用
李勇进,章晓云,曾浩..骨质疏松症病证结合动物模型的研究进展[J].中国实验动物学报,2024,32(6):772-785,14.基金项目
国家自然科学基金(82360937),广西自然科学基金面上项目(2023GXNSFAA026075),广西中医药适宜技术开发与推广项目(GZSY22-36),广西中医药多学科交叉创新资助课题(GZKJ2304),广西高校壮医毒病研究重点实验室(桂教科研[2022]10号),黄有荣桂派中医大师培养项目(桂中医药科教发[2022]6 号),广西中医药大学青年创新研究团队项目(2021TD001).Funded by National Natural Science Foundation of China(82360937),Guangxi Natural Science Foundation Project(2023GXNSFAA026075),Guangxi Traditional Chinese Medicine Appropriate Technology Development and Promotion Project(GZSY22-36),Guangxi Traditional Chinese Medicine Multidisciplinary Interdisciplinary Innovation Funding Project(GZKJ2304),Key Laboratory of Zhuang Medicine Poison Research in Guangxi Universities(Gui Jiao Research[2022]No.10),Huang Yourong Gui School TCM Master Training Project(Gui TCM Science and Education Fa[2022]No.6),Youth Innovation Research Team Project of Guangxi University of Chinese Medicine(2021TD001). （82360937）
