骨质疏松症病证结合动物模型的研究进展OA北大核心CSTPCD
Progress in the establishment and evaluation of osteoporosis disease and syndrome combination animal models
随着老龄化的加剧,骨质疏松症(osteoporosis,OP)的发病率逐年升高,已成为全球公共卫生问题之一.其主要特征为骨量降低及骨微结构破坏,临床上常表现为疼痛、驼背、身高降低,甚至出现骨折.积极进行与OP相关的科学研究显得尤为重要,动物模型的构建已经成为参与医药研究的关键手段之一,尤其是在探索新的治疗方法和药物开发过程.其中,融合了中医药特色的"病证结合"动物模型在我国中医药现代化研究中占据着不可替代的地位.本文从目前病证结合OP动物模型的现状出发,总结模型构建及评价方法,以期为病证结合OP动物模型的研究提供一定的思路及参考.
With increased population aging,the incidence of osteoporosis(OP)increases year by year,and has become a key global public health problem.Its main characteristics are reduced bone mass and damage to bone microstructure,often clinically manifesting as pain,hunched-back posture,height reduction,and even bone fractures.Therefore,it is particularly important to actively carry out scientific research related to OP,and the construction of animal models has become one of the key drivers of medical research,especially for exploring new treatments and in drug development.Animal models that are a"combination of disease and syndrome",integrating the characteristics of Chinese medicine,occupy an irreplaceable position in research aiming to modernize traditional Chinese medicines.On the basis of the current research status of disease-syndrome combination OP animal models,this paper summarizes model construction and evaluation method to provide certain ideas and references for research using these specialized OP animal models.
李勇进;章晓云;曾浩
广西中医药大学,南宁 530001广西中医药大学附属瑞康医院,南宁 530011
生物学
骨质疏松症病证结合动物模型研究进展
osteoporosiscombination of disease and syndromeanimal modelsresearch progress
《中国实验动物学报》 2024 (006)
772-785 / 14
国家自然科学基金(82360937),广西自然科学基金面上项目(2023GXNSFAA026075),广西中医药适宜技术开发与推广项目(GZSY22-36),广西中医药多学科交叉创新资助课题(GZKJ2304),广西高校壮医毒病研究重点实验室(桂教科研[2022]10号),黄有荣桂派中医大师培养项目(桂中医药科教发[2022]6 号),广西中医药大学青年创新研究团队项目(2021TD001).Funded by National Natural Science Foundation of China(82360937),Guangxi Natural Science Foundation Project(2023GXNSFAA026075),Guangxi Traditional Chinese Medicine Appropriate Technology Development and Promotion Project(GZSY22-36),Guangxi Traditional Chinese Medicine Multidisciplinary Interdisciplinary Innovation Funding Project(GZKJ2304),Key Laboratory of Zhuang Medicine Poison Research in Guangxi Universities(Gui Jiao Research[2022]No.10),Huang Yourong Gui School TCM Master Training Project(Gui TCM Science and Education Fa[2022]No.6),Youth Innovation Research Team Project of Guangxi University of Chinese Medicine(2021TD001).
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