听源性癫痫动物模型研究进展OA北大核心CSTPCD
Research progress in animal models of audiogenic seizures
听源性癫痫(audiogenic seizures,AGS)是由于强声刺激引起的癫痫,发作时伴全身性肌肉痉挛,其动物模型在研究癫痫发生机制、寻找致病基因及调控通道、筛选新的抗癫痫药物(antiepileptic drugs,AEDs)等方面具有重要意义.本文从发病特点、发病机制及致病基因等方面总结了目前常见AGS动物模型研究进展,以期为AEDs研发提供新的研究方向和靶点.
Audiogenic seizures(AGS)are the result of an epilepsy caused by strong acoustic stimulation and are characterized by generalized muscle spasms.AGS models are vital for studies of epileptogenesis,the search for causative genes and regulatory channels,and the screening of new antiepileptic drugs(AEDs).This paper summarizes the current progress of research on common animal models of AGS in terms of their pathogenetic features,possible pathogenesis,and causative genes to provide new research directions and targets for the development of AEDs.
翟文骥;吴杰;郑体花;郑庆印
滨州医学院特殊教育与康复学院,山东 烟台 264003
生物学
听源性癫痫动物模型抗癫痫药物
audiogenic seizuresanimal modelantiepileptic drugs
《中国实验动物学报》 2024 (006)
786-792 / 7
国家自然科学基金(81530030).Funded by National Natural Science Foundation of China(81530030).
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