低能量DPL联合柳兰提取物治疗面部红斑毛细血管扩张型玫瑰痤疮的临床观察OACSTPCD
Clinical Observation of DPL Combined with Epilobium Angustifolium Extract in the Treatment of Erthematotelangiectatic Rosacea
目的:观察低能量窄谱强脉冲光(Delicate pulsed light,DPL)联合柳兰提取物治疗面部红斑毛细血管扩张型玫瑰痤疮的疗效及安全性.方法:通过随机、自身半脸对照研究,对48例毛细血管扩张型玫瑰痤疮患者进行观察,随机将患者脸部分为观察侧及DPL侧.其中观察组为一侧面部采用低能量窄谱强脉冲光联合柳兰提取物治疗,DPL组为另一侧面部给予低能量DPL单独治疗,每1个月治疗1次,共治疗3～4次.治疗前、治疗后根据总有效率、皮肤病生活质量指数(Dermatology life quality index,DLQI)量表进行评分,进行VISIA分析,分析两组治疗前后红色区、毛孔、棕色斑、紫质,同时通过应用皮肤多功能弹性测试仪分析两组治疗前后皮肤弹性、角质层含水量、经表皮水分流失值(TWEL).并对患者进行满意度评价,在治疗期间及随访期,询问并记录患者不良反应.结果:治疗3～4次后,观察组总有效率为83.33%(40/48),明显高于DPL组70.83%(34/48),差异具有统计学意义(P＜0.05);观察组皮肤病生活质量指数(DLQI)评分低于对照组(P＜0.05);观察组治疗后皮肤图像各项评分均高于对照组(P＜0.05);观察组治疗后皮肤屏障功能指标皮肤弹性、角质层含水量评分均高于对照组,经表皮水分流失值评分低于对照组(P＜0.05).各组均无严重不良反应发生.结论:DPL联合柳兰提取物治疗面部红斑毛细血管扩张型玫瑰痤疮的疗效优于单独使用DPL治疗,且安全性良好.
Objective To observe the efficacy and safety of delicate pulsed light(DPL)combined with epilobium angustifolium extract in the treatment of erythematotelangiectatic rosacea.Methods A total of 48 patients with erythematotelangiectatic rosacea underwent a randomized,split-face study,which divided them into two groups:the observation group and the DPL group.The observation group received treatment with low-energy narrow-spectrum intense pulsed light combined with epilobium angustifolium extract,while the DPL group received treatment with low-energy narrow-spectrum intense pulsed light alone.Treatment was administered once a month for 3-4 months.Before and after the treatment,scores were evaluated based on the total effective rate and dermatology life quality index(DLQI)scale.The VISIA analysis was performed to analyze redness,pores,brown spots,and melanin in the two groups before and after treatment.Additionally,skin elasticity,stratum corneum hydration,and transepidermal water loss(TEWL)were analyzed in the two groups before and after treatment using a multifunctional skin elasticity tester.Patient satisfaction was evaluated during the treatment and follow-up period.Results After 3-4 treatments,the total effective rate of the observation group was 83.33%(40/48),which was significantly higher than the DPL group's 70.83%(34/48),and the difference was statistically significant(P＜0.05).The Dermatology Life Quality Index(DLQI)score of the observation group was lower than that of the control group(P＜0.05).The skin image scores of various items in the observation group after treatment were higher than those in the control group(P＜0.05).The skin barrier function indicators of the observation group,including skin elasticity and stratum corneum water content score,were higher than those of the control group,and the transepidermal water loss score was lower than that of the control group(P＜0.05).No serious adverse reactions occurred in any group.Conclusion DPL combined with epilobium angustifolium extract is more effective than DPL alone,providing a better treatment plan for clinicians.
赵媛媛;韩莎;雷文鸽;颉红霞;张梦葩;王一清;向雪岑
西安交通大学口腔医院美容整形外科 陕西 西安 710032西安大兴医院口腔科 陕西 西安 710082向雪岑皮肤管理中心 四川 成都 610014
临床医学
窄谱强脉冲光光调作用柳兰提取物红斑毛细血管扩张型玫瑰痤疮
delicate pulsed lightphotomodulationepilobium angustifolium extracterythematotelangiectaticrosacea
《中国美容医学》 2024 (007)
15-18 / 4
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