中国实验动物学报2024，Vol.32Issue(6)：793-798,6.DOI:10.3969/j.issn.1005-4847.2024.06.012
DMD模型鼠mdx小鼠线粒体损伤的研究进展
Progress of research into mitochondrial injury in mdx mice
摘要
Abstract
Duchenne muscular dystrophy(DMD)is a lethal,progressive,X-linked recessive hereditary muscle disease caused by a mutation in the gene encoding dystrophin.Currently,no cure for DMD is available,and clinical research is progressing slowly.The establishment of animal models is becoming increasingly important for experimental research on DMD.Following the research findings that mdx mice have the same pathogenesis as DMD patients,this model is widely used in the study of DMD pathogenesis and drug development.Mitochondrial injury is one of the most important pathological mechanisms of DMD,and mitochondrial protection is a potential therapeutic strategy for DMD,and thus it is significant to study mitochondrial injury in mdx mice.This article reviews the progress of research into mitochondrial injury in DMD model mdx mice in recent years to provide a reference for related experiments.关键词
Duchenne肌营养不良/线粒体损伤/动物模型/mdx小鼠Key words
Duchenne muscular dystrophy/mitochondrial injury/animal model/mdx mice分类
生物科学引用本文复制引用
高天,董健健,喻绪恩..DMD模型鼠mdx小鼠线粒体损伤的研究进展[J].中国实验动物学报,2024,32(6):793-798,6.基金项目
安徽省高校自然科学研究重点项目(KJ2021A0550),安徽中医药大学临床科研自然重大项目(2021sfylc02).Funded by the Key Project of Natural Science Research Project of Universities in Anhui Province(KJ2021A0550),Anhui University of Chinese Medicine Clinical Research Natural Major Project(2021sfylc02). （KJ2021A0550）
