中国实验动物学报2024，Vol.32Issue(6)：799-818,20.DOI:10.3969/j.issn.1005-4847.2024.06.013
雪貂在抗感染药物非临床研究中的应用
Use of ferrets in nonclinical studies of anti-infective drugs
摘要
Abstract
Ferrets offer an advantage in nonclinical studies of anti-infective drugs because of their ability to be infected with and spread pathogenic microorganisms,especially viral strains,without the need for host adaptation.Additionally,the clinical symptoms exhibited by infected ferrets are very similar to those of humans.Although ferrets play a very important role in the research and development of antiviral drugs,the scope of their application remains limited.This may be related to the lack of corresponding national standards for laboratory animal feeding and application of ferrets as well as the lack of specific diagnostic and detection reagents.This paper summarizes the characteristics of ferrets as infectious disease models with a summary and analysis of the application direction of ferrets in anti-infective drug research.Our aim is to promote further standardization of the use of ferrets.关键词
雪貂/抗感染药物/标准/实验动物Key words
ferret/anti-infective drugs/standards/laboratory animal分类
生物科学引用本文复制引用
刘学武,唐梓宁,彭冬冬,杜艳华,姜德建..雪貂在抗感染药物非临床研究中的应用[J].中国实验动物学报,2024,32(6):799-818,20.基金项目
湖南省药物非临床研究科技创新创业团队(2021),湖南省重点研发计划(2023DK2006),"小荷"青年人才创新项目((2022)056).Funded by Scientific and Technological Innovation and Entrepreneurship Team of Pharmaceutical Non-Clinical Research in Hunan Province(2021),Hunan Province Key Research and Development Project(2020DK2003),"Xiao He"Youth Talent Innovation Project((2022)056). （2021）
