雪貂在抗感染药物非临床研究中的应用OA北大核心CSTPCD
Use of ferrets in nonclinical studies of anti-infective drugs
雪貂应用于抗感染药物评价的优势在于病原微生物(尤其是病毒株)能不经宿主适应直接进行感染和传播,且动物感染后的临床症状与人极为相似.虽然雪貂在抗病毒药物的研发中起到了极为重要的作用,但其应用范围仍有一定的局限性,可能与雪貂缺少相应的实验动物饲养和应用的国家级标准,缺乏特异性的诊断和检测试剂等因素有关.本文对雪貂作为感染疾病模型的特点进行总结,并汇总分析了雪貂在抗感染药物研究中的应用方向,旨在促进雪貂作为实验动物的标准化应用.
Ferrets offer an advantage in nonclinical studies of anti-infective drugs because of their ability to be infected with and spread pathogenic microorganisms,especially viral strains,without the need for host adaptation.Additionally,the clinical symptoms exhibited by infected ferrets are very similar to those of humans.Although ferrets play a very important role in the research and development of antiviral drugs,the scope of their application remains limited.This may be related to the lack of corresponding national standards for laboratory animal feeding and application of ferrets as well as the lack of specific diagnostic and detection reagents.This paper summarizes the characteristics of ferrets as infectious disease models with a summary and analysis of the application direction of ferrets in anti-infective drug research.Our aim is to promote further standardization of the use of ferrets.
刘学武;唐梓宁;彭冬冬;杜艳华;姜德建
中山大学中山医学院药理教研室,广州 510080||湖南普瑞玛药物研究中心有限公司&新药药效与安全性评价湖南省重点实验室,长沙 410329湖南普瑞玛药物研究中心有限公司&新药药效与安全性评价湖南省重点实验室,长沙 410329中山大学中山医学院药理教研室,广州 510080
生物学
雪貂抗感染药物标准实验动物
ferretanti-infective drugsstandardslaboratory animal
《中国实验动物学报》 2024 (006)
799-818 / 20
湖南省药物非临床研究科技创新创业团队(2021),湖南省重点研发计划(2023DK2006),"小荷"青年人才创新项目((2022)056).Funded by Scientific and Technological Innovation and Entrepreneurship Team of Pharmaceutical Non-Clinical Research in Hunan Province(2021),Hunan Province Key Research and Development Project(2020DK2003),"Xiao He"Youth Talent Innovation Project((2022)056).
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