中国全科医学2024，Vol.27Issue(29)：3623-3628,6.DOI:10.12114/j.issn.1007-9572.2024.0147
中国汉族成年人群单不饱和脂肪酸摄入量与非酒精性脂肪性肝病风险关系的回顾性病例对照研究
Association of Monounsaturated Fatty Acid Intake with Nonalcoholic Fatty Liver Disease Risk in Chinese Han Adults:a Retrospective Case-control Study
摘要
Abstract
Background While the connection between monounsaturated fatty acid(MUFA)intake and non-alcoholic fatty liver disease(NAFLD)has received attention,research in Chinese populations remains scarce.Objective This study aims to evaluate the association between daily MUFA intake and the prevalence of NAFLD in a Chinese population and to estimate the probable threshold of MUFA intake for NAFLD risk.Methods This case-control study employed data from the Dryad database(https://doi.org/10.5061/dryad.8nn2j46),complying with Dryad's terms of service.We collected data from 534 NAFLD patients and 534 healthy controls who underwent medical tests at the First Hospital of Nanping Affiliated to Fujian Medical University between April 2015 and August 2017.A semi-quantitative food frequency questionnaire(SQFFQ)was used to collect individuals'typical food consumption information,and daily MUFA intake was computed.A thorough analytical technique,including baseline characteristics,multivariate statistics,non-linear relationship analysis,and subgroup research,was applied to study the correlation between daily MUFA intake and NAFLD prevalence.Multiple confounding factors,such as age,sex,lifestyle,and other dietary components,were evaluated to estimate the theoretical threshold of MUFA intake for NAFLD risk.Results In the adjusted model,daily MUFA intake was a significant risk factor for NAFLD(OR=1.04,95%CI=1.02-1.07,P<0.001).After transforming daily MUFA intake into a categorical variable,the adjusted model demonstrated an increased trend of NAFLD risk with increasing daily MUFA intake(Ptrend<0.001).At 39.04 g/d,non-linear analysis revealed a significant change in the relationship between daily MUFA intake and NAFLD risk.When daily MUFA intake was<39.04 g/d,the risk of NAFLD was 1.08(95%CI=1.04-1.11,P<0.001).Subgroup analysis revealed significant interactions between sex,age,daily engery intake,and NAFLD risk(Pinteraction<0.05).Conclusion Increased daily MUFA intake was related to a greater risk of NAFLD,demonstrating a non-linear relationship after a certain threshold(39.04 g/d).This finding shows the need for evaluating both the quality and quantity of dietary fat in NAFLD management.关键词
非酒精性脂肪性肝病/单不饱和脂肪酸/饮食脂肪/风险因素/非线性关系Key words
Non-alcoholic fatty liver disease/Monounsaturated fatty acids/Dietary fat/Risk factors/Nonlinear relationship分类
医药卫生引用本文复制引用
付伟,程国彬,吕麟亚,丁瑶,王瑶,赵俊龙..中国汉族成年人群单不饱和脂肪酸摄入量与非酒精性脂肪性肝病风险关系的回顾性病例对照研究[J].中国全科医学,2024,27(29):3623-3628,6.基金项目
国家自然科学基金面上项目(82173082,82373270) （82173082,82373270）
中国博士后科学基金(2021M639344) （2021M639344）
中国博士后(站中)特别资助(2022T150792) （站中）
联勤保障部队第925医院院内课题(No.2023[3],No.2022[3],No.2022[4]) （No.2023[3],No.2022[3],No.2022[4]）
