中国全科医学2024，Vol.27Issue(29)：3629-3634,6.DOI:10.12114/j.issn.1007-9572.2024.0095
慢性阻塞性肺疾病患者身体成分与心肺运动能力的相关性研究
Correlation between Body Composition and Cardiopulmonary Exercise Capacity in Patients with Chronic Obstructive Pulmonary Disease
摘要
Abstract
Background Cardiopulmonary exercise testing(CPET)is essential for assessing the maximal exercise capacity of patients with chronic obstructive pulmonary disease(COPD)and for developing rehabilitation prescriptions.Body composition has been shown to be associated with CPET results,which is complex,time-consuming,contraindicated,and risky,and cannot be performed in some COPD patients,whereas body composition analysis is simple and fast.Objective This paper focuses on the correlation between body composition and CPET in patients with COPD,and provides a basis for predicting maximal exercise capacity,formulating rehabilitation prescriptions,and rational nutritional support for patients with COPD who are unable to complete cardiopulmonary exercise testing.Methods Stable COPD patients were enrolled in the outpatient respiratory clinic of China-Japan Friendship Hospital between July 2021 and March 2022,and were sequentially subjected to body composition measurements and CPET with continuous incremental loading,and the test results were analyzed to assess the relationship between body composition and CPET results,and to analyze the value of the body composition indexes in predicting the results of CPET.Results Seventy-seven eligible patients with stable COPD completed body composition measurement and exercise cardiopulmonary exercise testing.Correlation analysis showed that body fat percentage(BFP)was negatively correlated with peak metabolic equivalents(peakMETs)(P<0.01);skeletal muscle mass index(SMI)was positively correlated with peak oxygen uptake(peakVO2),peak load,peak ventilation volume(peakVE),maximum heart rate(peakHR),peak oxygen pulse(peakO2pulse),and oxygen uptake efficiency slope(OUES)at the highest exercise state were positively correlated(P<0.01);and the fat free mass index(FFMI)was positively correlated with peakVO2,peakLoad,peakVE,peakO2pulse,and OUES(P<0.01).The results of multivariable linear regression analysis showed that SMI and FFMI were independently and positively correlated with peakLoad,peakVE,peakO2pulse,and OUES in patients with COPD(P<0.05).BFP was independently and negatively correlated with peakMETs in patients with COPD(P<0.05).SMI had better predictive ability than FFMI for the results of the CPET trial in COPD patients peakLoad,peakVE,peakO2pulse,and OUES.Conclusion Muscle content is positively correlated with the exercise capacity of COPD patients,and the results of body composition measurement can be used as an important criterion for predicting the exercise capacity of COPD patients,guiding the rehabilitation exercise and rational nutritional support therapy.关键词
慢性阻塞性肺疾病/心肺运动试验/身体成分/康复/多元线性回归Key words
Chronic obstructive pulmonary disease/Cardiopulmonary exercise test/Body composition/Rehabilitation/Multifactor linear regression分类
医药卫生引用本文复制引用
于春艳,董芬,雷洁萍,杨汀,夏金根,曲木诗玮,杨天祎,李晓盼..慢性阻塞性肺疾病患者身体成分与心肺运动能力的相关性研究[J].中国全科医学,2024,27(29):3629-3634,6.基金项目
中国医学科学院医学与健康科技创新工程(2021-12M-1-049) （2021-12M-1-049）
