3-乙酰基-7-羟基香豆素衍生物的设计、合成及抗血小板聚集活性OA北大核心CSTPCD
Design,synthesis and antiplatelet aggregation activity of 3-acetyl-7-hydroxycoumarin derivatives
为寻找安全有效的抗血小板聚集药物,以间苯二酚为起始原料,经Vilsmeier-Haack反应、Knoevenagel反应制备先导化合物 3-乙酰基-7-羟基-香豆素;再对其 7-位羟基进行氨基烷基醚化,3-位酮羰基肟化,得到 25个目标化合物(6a～6y).所合成的目标化合物的结构经过高分辨质谱、核磁共振氢谱和红外光谱确证.采用Bron比浊法分别测试了目标化合物对二磷酸腺苷(ADP)、胶原、花生四烯酸(AA)和凝血酶诱导的血小板聚集的抑制作用.结…查看全部>>
In order to search for coumarin-based anti-platelet aggregation compounds with high efficacy and good druggability,twenty-five 3-acetyl-7-hydroxy-coumarin oxime derivatives(6a-6y)were synthesized via Vilsmeier-Haack reaction,Knoevenagel reaction,Williamson reaction,electrophilic substitution reaction and oximation reaction from resorcinol.Their structures were confirmed by HRMS and 1H NMR spectra.The anti-platelet aggregation activity of the target compounds…查看全部>>
尚飞扬;刘成波;谭鸿舟;何冰;何黎琴
安徽中医药大学药学院,合肥 230038安徽中医药大学药学院,合肥 230038安徽中医药大学药学院,合肥 230038安徽中医药大学药学院,合肥 230038安徽中医药大学药学院,合肥 230038
药学
3-乙酰基-7-羟基-香豆素肟水溶性抗血小板聚集
3-acetyl-7-hydroxy-coumarinoximeaqueous solubilityanti-platelet aggregation
《中国药科大学学报》 2024 (3)
367-374,8
This study was supported by the Natural Science Foundation of Department of Education of Anhui Province(No.KJ2020A0957,No.KJ2021B003) 安徽省教育厅自然科学科研项目(No.KJ2020A0957,No.KJ2021B003)
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