中国全科医学2024，Vol.27Issue(29)：3696-3703,8.DOI:10.12114/j.issn.1007-9572.2023.0381
儿童紫癜性肾炎临床研究结局指标的范围综述
Clinical Study Outcome Indicators for Henoch-Schonlein Purpura Nephritis:a Scoping Review
摘要
Abstract
Background Henoch-Schonlein purpura is a vascular inflammatory illness that develops in childhood and in some children involves the kidneys,clinically known as Henoch-Schonlein purpura nephritis.Different studies have suggested different interventions,and there is a wide variation in the outcome indicators used for the intervention approaches.Objective To investigate and analyze the current status of clinical research outcome indicators for Henoch-Schonlein purpura nephritis in China,so as to provide a reference basis for the establishment of a core set of outcome indicators in this field.Methods CNKI,CBM,VIP,Wanfang Data,PubMed,Cochrane Library,Embase and Web of Science were systematically searched to collect publicly available Henoch-Schonlein purpura nephritis studies from January 2010 to June 2021.The Chinese databases were searched using the search strategy of title or keywords combined with subject terms,and the English databases were searched using subject terms combined with free words.Two investigators independently screened the literature and extracted information according to the inclusion and exclusion criteria,processed and analyzed the data on outcome indicators.Results A total of 148 randomized controlled trials of Henoch-Schonlein purpura nephritis were included,and the outcome indicators of Henoch-Schonlein purpura nephritis studies were mainly physical and chemical indicators,with fewer symptomatic indicators.The highest frequency of outcome indicators were clinical efficacy(121 times,81.76%),adverse reactions(74 times,50.00%),24-hour urine protein(68 times,45.95%),urinary red blood cells(43 times,29.05%),and recurrence rate(20 times,13.51%).The division between primary and secondary outcome indicators was clearly distinguished in only two articles.Conclusion There are several indicators for the research outcomes of Henoch-Schonlein purpura nephritis in China,primarily physical and chemical variables,with significant variation.The research focuses on efficacy measures but ignores adverse reactions.As a result,it is necessary to establish a set of outcome indicators for clinical intervention studies on Henoch-Schonlein purpura nephritis in order to provide a reference basis for selecting outcome indicators and guiding clinical decision-making in future similar studies.关键词
紫癜性肾炎/过敏性紫癜/儿童/结局指标/结局指标集/范围综述Key words
IgA vasculitis nephritis/Henoch-Schonlein purpura/Child/Outcome indicators/Set of outcomes/Scoping review分类
医药卫生引用本文复制引用
佟静涵,刘雅莉,吴晓明,孙雅欣,李姝凝,梁琛,董恒,车刚,刘畅,胡艳..儿童紫癜性肾炎临床研究结局指标的范围综述[J].中国全科医学,2024,27(29):3696-3703,8.基金项目
北京市研究型病房建设示范单位项目(BCRW2202101) （BCRW2202101）
北京市中医药科技发展重点项目(BJZYZD-2023-03) （BJZYZD-2023-03）
首都医科大学"本科生科研创新"项目(XSKY2021337) （XSKY2021337）
