前列腺癌根治术联合间断抗雄激素对前列腺癌患者肿瘤标志物及疾病预后的影响OA

Objective:To investigate the effect of radical prostatectomy combined with intermittent antiandrogen on tumor markers and disease prognosis of prostate cancer.Method:A total of 66 patients with prostate cancer admitted to Fuzhou Second Hospital from January 2018 to June 2022 were divided into control group(n=33)and observation group(n=33)according to random number table method.Patients in the control group simply underwent radical prostatectomy by three-hole method via peritoneal laparoscopy.Observation group received radical prostatectomy by three-hole transperitoneal laparoscopy combined with intermittent antiandrogen.The operation indexes of both groups were compared,and the hemoglobin drop was calculated 1 week after operation,prostate-specific antigen(PSA),prostate acid phosphatase,tumor patient quality of life(QOL)score,and international index erectile function(IIEF-5)score before and 12 months after treatment were compared between the two groups,postoperative complications and 1-year postoperative recurrence rates were analyzed.Result:The decrease of hemoglobin in observation group was(22.68±5.18)g/L,which was significantly lower than(27.53±5.22)g/L in control group;the indentation time of urinary catheter in the observation group was(5.55±1.40)d,which was significantly shorter than(8.60±1.66)d in the control group;the length of hospitalization in the observation group was(8.46±2.42)d,which was significantly shorter than(10.30±2.10)d in the control group,the differences were statistically significant(P<0.05).After treatment,the PSA and prostate acid phosphatase in the observation group were(2.51±0.74)ng/mL and(2.06±0.58)μg/L respectively,which were significantly lower than[(254.84±60.28)ng/mL,(23.66±6.42)μg/L]before treatment and[(17.25±1.88)ng/mL,(9.35±1.86)μg/L]in the control group,the differences were statistically significant(P<0.05).After treatment,the score of QOL in the observation group was(44.22±2.56)points,which was significantly higher than(40.12±6.58)points before treatmentand and(42.57±3.76)points in the control group,the differences were statistically significant(P<0.05).After treatment,the score of IIEF-5 in the observation group was(17.96±1.46)points,significantly higher than(14.96±1.10)points in the control group,the difference was statistically significant(P<0.05).The complication rates of observation group and control group were 3.03%and 18.18%,the difference was statistically significant(P<0.05).The 1-year recurrence rates of observation group and control group were 0 and 15.15%,the difference was statistically significant(P<0.05).Conclusion:Radical prostatectomy combined with intermittent antiandrogen therapy can effectively reduce the level of PSA in patients with prostate cancer,promote postoperative rehabilitation,reduce the incidence of complications and improve the quality of life.