Abstract
Objective:To investigate the effect of percutaneous nephrolithotomy(PCNL)on renal function indicators,incidence of complications and quality of life in patients with kidney stones.Method:A total of 520 cases of kidney stones admitted to Guiyang Guihang Hospital from March 2021 to March 2023 were selected,and were divided into two groups by the random number table method,with 260 cases in each group.The control group was treated with open lithotomy,and the observation group with PCNL.Surgical index,renal function index,stress response,quality of life,and incidence of complications were compared between the two groups.Result:The surgical time,postoperative mobilization time,and hospital stay in the observation group were(78.96±5.37)min,(3.02±0.36)d,and(7.62±1.12)d,which were better than(102.41±10.35)min,(6.57±1.22)d,and(12.35±1.24)d in the control group,the intraoperative blood loss was(85.41±6.38)mL,which was lower than(149.85±12.54)mL in the control group,the differences were statistically significant(P<0.05).24 hours after surgery,the levels of blood urea nitrogen(BUN),creatinine(Cr),and cystatin C(Cys C)in the observation group were(10.95±1.23)mmol/L,(89.04±7.75)μmol/L,and(622.41±50.28)μg/L,which were lower than(14.98±1.31)mmol/L,(96.85±7.82)μmol/L,and(693.68±50.75)μg/L in the control group,the differences were statistically significant(P<0.05).24 hours after surgery,the levels of adrenocortical hormone(ACTH),norepinephrine(NE),and cortisol(Cor)in the observation group were(88.63±7.35)μg/L,(23.56±2.31)pmol/L,and(748.65±50.34)nmol/L,which were lower than(96.78±8.53)μg/L,(27.63±3.15)pmol/L,and(803.41±52.54)nmol/L in the control group,the differences were statistically significant(P<0.05).Three months after surgery,the quality of life scores in various fields in the observation group were(87.86±5.62),(89.44±5.93),(90.33±4.39),and(91.52±4.23)points,which were higher than(82.23±5.31),(83.14±5.52),(83.68±5.12),and(85.46±5.59)points in the control group,the differences were statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:PCNL has better results in the treatment of kidney stones,which can reduce the body stress response,reduce renal function damage,and reduce complications.关键词
肾结石/经皮肾镜碎石取石术/肾功能/生活质量/并发症Key words
Kidney stones/Percutaneous nephrolithotomy/Renal function/Quality of life/Complications
