中国医学创新2024，Vol.21Issue(17)：41-45,5.DOI:10.3969/j.issn.1674-4985.2024.17.010
预防性使用氨甲环酸减少高危妊娠剖宫产出血的临床观察
Clinical Observation of Prophylactic Use of Tranexamic Acid to Reduce Bleeding during Caesarean Section of High-risk Pregnancy
摘要
Abstract
Objective:To observe the clinical effect of prophylactic use of Tranexamic Acid in reducing bleeding during caesarean section of high-risk pregnancy.Method:Eighty high-risk pregnant women admitted to Pingxiang Maternal and Child Health Hospital from August 2021 to December 2023 were selected,all of whom were terminated by cesarean section,and divided into observation group(n=40)and control group(n=40)according to random number table method.20 min before operation,the observation group added 1.0 g Tranexamic Acid Injection into 100 mL 0.9%Sodium Chloride Injection,and the control group received intravenous infusion of 120 mL of Compound Sodium Chloride Injection.After the umbilical cord was cut,both groups were given intrauterine injection of 10 U of Oxytocin Injection.The differences of perioperative parameters,postpartum hemorrhage and coagulation function[prothrombin time(PT),D-dimer(D-D),etc]between the two groups were compared,and the incidence of neonatal adverse events and adverse reactions were compared between the two groups.Result:The length of hospital stay and duration of lochia rubra in the observation group were shorter than those in the control group,and the amount of Oxytocin was less than that in the control group,the duration of uterine contraction in the observation group was longer than that in the control group,and the descending speed of uterine floor was greater than that in the control group(P<0.05);there was no statistically significant difference in operation time between the two groups(P>0.05).The amount of blood loss during childbirth,2 h and 24 h after surgery and the rate of postpartum hemorrhage in the observation group were lower than those in the control group(P<0.05).Fibrinogen(FIB)and fibrinogen degradation product(FDP)in both groups 24 h after operation were higher than those before operation,activated partial thromboplastin time(APTT)and PT were shorter than those before operation,D-D were lower than those before operation,FIB and FDP in observation group were higher than those in control group 24 h after operation,APTT and PT were shorter than those in control group,and D-D was lower than that of control group(P<0.05).There were no significant differences in the incidence of neonatal asphyxia and the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Prophylactic administration of Tranexamic Acid before operation can promote postpartum recovery,significantly reduce bleeding and regulate coagulation function,but does not increase the risk of neonatal adverse events and adverse reactions.关键词
预防/氨甲环酸/高危妊娠/剖宫产/产后出血Key words
Prevention/Tranexamic Acid/High-risk pregnancy/Cesarean section/Postpartum hemorrhage引用本文复制引用
王珊,张劲宜,李月芬,刘俊..预防性使用氨甲环酸减少高危妊娠剖宫产出血的临床观察[J].中国医学创新,2024,21(17):41-45,5.基金项目
萍乡市科技计划项目(2023PY121) （2023PY121）
