摘要
Abstract
Objective:To investigate the predictive value of serum heart-type fatty acid binding protein(H-FABP)and growth and differentiation factor-15(GDF-15)expression for adverse cardiovascular events in patients with ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Method:A prospective study was conducted,140 STEMI patients who received PCI treatment in Ganzhou People's Hospital from June 2020 to June 2023 were selected as the study subjects.Serum H-FABP and GDF-15 were detected before operation,and PCI was performed.The patients were followed up for 3 months after operation,and the incidence of adverse cardiovascular events was counted.The relationship between serum H-FABP,GDF-15 and postoperative adverse cardiovascular events in STEMI patients was analyzed.At the same time,receiver operating characteristic(ROC)was drawn to explore the predictive value of serum H-FABP and GDF-15 for adverse cardiovascular events in STEMI patients after PCI.Result:During the follow-up period of 3 months,140 patients had no shedding cases.During the follow-up period,among 140 STEMI patients,23.57%(33/140)had adverse cardiovascular events after PCI,and 76.43%(107/140)had no adverse cardiovascular events.There were significant differences in myocardial infarction size,hypertension and smoking history between the two groups(P<0.05).There were no significant differences in gender,age,number of lesions,previous drinking history,myoglobin(Myo),cardiac troponin I(cTnI),creatine kinase-MB(CK-MB),left ventricular end diastolic dimension(LVEDD)between the two groups(P>0.05).Serum H-FABP and GDF-15 in the occurrence group were higher than those in the non-occurrence group,and the differences were statistically significant(P<0.05).Point two-column correlation analysis showed that serum H-FABP and GDF-15 were positively correlated with adverse cardiovascular events after PCI in STEMI patients(r>0,P<0.05).ROC curve results showed that the AUC predicted by serum H-FABP and GDF-15 alone was>0.7,and the AUC predicted by combination was>0.8,and the combined prediction value was higher.Conclusion:The higher the serum levels of H-FABP and GDF-15 before PCI in STEMI patients,the greater the risk of postoperative adverse cardiovascular events,and serum H-FABP and GDF-15 can be used as effective predictive indicators for adverse cardiovascular events in STEMI patients after PCI in clinical practice.关键词
ST段抬高型心肌梗死/经皮冠状动脉介入治疗/心型脂肪酸结合蛋白/生长分化因子-15/不良心血管事件Key words
ST-segment elevation myocardial infarction/Percutaneous coronary intervention/Heart-type fatty acid binding protein/Growth and differentiation factor-15/Adverse cardiovascular events
