中国医学创新2024，Vol.21Issue(18)：148-152,5.DOI:10.3969/j.issn.1674-4985.2024.18.034
术前SII、PNI对子宫颈癌淋巴结转移的预测价值
Prognostic Value of Preoperative SII and PNI in Cervical Cancer with Lymph Node Metastasis
孙冰 1刘玮萱 2张慧勤 1汤井娇 1钱卫卫 3王磊1
作者信息
- 1. 锦州医科大学研究生培养基地(连云港市第一人民医院)肿瘤放疗科 江苏 连云港 222000
- 2. 锦州医科大学研究生培养基地(连云港市第一人民医院)肿瘤内科 江苏 连云港 222000
- 3. 锦州医科大学研究生培养基地(连云港市第一人民医院)妇科 江苏 连云港 222000
- 折叠
摘要
Abstract
Objective:To explore the predictive value of preoperative systemic immunoinflammatory index(SII)and prognostic nutritional index(PNI)in cervical cancer with lymph node metastasis.Method:Clinical data of 131 patients with cervical cancer treated in Lianyungang First People's Hospital from January 2021 to January 2023 were retrospectively collected.The patients were divided into lymph node metastasis group(n=42)and lymph node non-metastatic group(n=89)according to the pathological results after surgery.Clinical data and related indicators(preoperative SII,PNI,etc.)of the two groups were collected,and univariate and multivariate logistic regression analysis was performed to analyze the risk factors affecting cervical cancer lymph node metastasis.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of SII and PNI levels in cervical cancer with lymph node metastasis.Result:The levels of SII,neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153)and low tumor differentiation ratio in lymph node metastasis group were higher than those in lymph node non-metastasis group,while PNI was lower than that in lymph node non-metastasis group,the differences were statistically significant(P<0.05).There were no significant differences in platelet content,hemoglobin content,whether menopause,whether vascular invasion,whether uterine body invasion,whether human papillomavirus(HPV)infection and pathological classification between the two groups(P>0.05).SII,PNI,CA153 and differentiation classification were the independent influencing factors of lymph node metastasis in patients with cervical cancer(P<0.05).The area under the curve of the combined prediction of SII and PNI was 0.898,the sensitivity was 80.65%,and the specificity was 91.03%,which had good clinical diagnostic value.Conclusion:SII and PNI are independent factors affecting cervical cancer with lymph node metastasis,and the combined detection of SII and PNI before surgery can effectively help clinicians judge the results of lymph node metastasis of cervical cancer.关键词
子宫颈癌/全身免疫炎症指数/预后营养指数/淋巴结转移/预测价值Key words
Cervical cancer/Systemic immune inflammatory index/Prognostic nutritional index/Lymph node metastasis/Predictive value引用本文复制引用
孙冰,刘玮萱,张慧勤,汤井娇,钱卫卫,王磊..术前SII、PNI对子宫颈癌淋巴结转移的预测价值[J].中国医学创新,2024,21(18):148-152,5.
