中国医学创新2024，Vol.21Issue(18)：157-160,4.DOI:10.3969/j.issn.1674-4985.2024.18.036
不同临床病理特征卵巢浆液性肿瘤患者E-cadherin、BRCA1及P53的表达变化研究
Study on the Expression Change of E-cadherin,BRCA1 and P53 of Patients with Different Clinicopathological Characteristics of Ovarian Serous Tumor
摘要
Abstract
Objective:To investigate the expression change of E-cadherin,Breast cancer susceptibility gene 1(BRCA1),and P53 in patients with different clinicopathological characteristics of ovarian serous tumors.Method:A total of 50 patients with ovarian serous carcinoma in Ganzhou Women and Children's Health Care Hospital from December 2017 to February 2022 were selected as group A,40 patients with ovarian borderline serous tumor at the same time were selected as group B,and 30 patients with ovarian benign serous cystadenoma were selected as group C.The expression of tissues E-cadherin,BRCA1,and P53 of three groups of were detected and compared,and the detection results of group A with different age,lymph node metastasis,FIGO stages and different pathological grades were compared.Result:The positive rates of E-cadherin and BRCA1 in group A were significantly lower than those of group B and group C,those in group B were significantly lower than those in group C(P<0.05);the positive rate of P53 in group A was significantly higher than that of group B and group C,that in group B was significantly higher than that in group C(P<0.05).The positive rate of E-cadherin and BRCA1 in low-grade serous cancer patients in group A were higher than those in high-grade serous cancer patients;the positive rate of P53 in low-grade serous cancer patients was significantly lower than that in high-grade serous cancer patients,the differences were statistically significant(P<0.05).There were no statistically significant differences in the positive rates of E-cadherin,BRCA1,and P53 in tissues of patients of different ages and FIGO stages in group A(P>0.05).The positive rates of E-cadherin and BRCA1 in patients with lymph node metastasis in group A were lower than those without lymph node metastasis,and the positive rate of P53 in patients with lymph node metastasis was higher than those without lymph node metastasis,the differences were statistically significant(P<0.05).Conclusion:E-cadherin and BRCA1 are low expression in patients with ovarian serous cancer,while P53 is high expression,and the differences of patients with different clinicopathological characteristics are significant,so that may have certain reference value in early screening and detection of ovarian serous cancer.关键词
卵巢浆液性肿瘤/E-钙黏蛋白/乳腺癌易感基因1/P53/临床病理Key words
Ovarian serous tumor/E-cadherin/Breast cancer susceptibility gene 1/P53/Clinical pathology引用本文复制引用
陈冬莲,李红红,叶倩倩..不同临床病理特征卵巢浆液性肿瘤患者E-cadherin、BRCA1及P53的表达变化研究[J].中国医学创新,2024,21(18):157-160,4.基金项目
江西省卫生健康委科技计划项目(202312059) （202312059）
