摘要
Abstract
Objective:To investigate the predictive value of changes of plasma heart-type fatty acid binding protein(H-FABP),thrombin activated fibrinolytic inhibitor(TAFI)and plasminogen activator inhibitor-1(PAI-1)on vascular recanalization after intravenous thrombolysis treatment in patients with ST segment elevation acute myocardial infarction(STEMI).Method:The clinical data of 150 STEMI patients admitted to Yantai Affiliated Hospital of Binzhou Medical University from May 2017 to May 2022 were retrospectively analyzed,and the clinical data of another 150 healthy medical checkups during the same period were selected as the control group.The STEMI patients were classified into 89 cases in the recanalized group and 61 cases in the uncanalized group according to the criteria of vascular recanalization.The plasma levels of H-FABP,TAFI,and PAI-1 between STEMI patients before thrombolysis and the control group were compared,the clinical data of the recanalized group and the uncanalized group were compared,the changes in plasma levels at different time points before and after thrombolysis in STEMI patients were compared,the predictive value of the above plasma levels on vascular reperfusion in patients were analyzed,and receiver operating characteristic(ROC)curves was plotted.Result:The levels of plasma H-FABP,TAFI and PAI-1 in patients with STEMI before thrombolysis were higher than those in the control group,the differences were statistically significant(P<0.05);compared with the pre-thrombolytic period,the plasma H-FABP,TAFI and PAI-1 levels in the recanalized group and the uncanalized group showed a trend of increasing first and decreasing second after thrombolysis.The level of H-FABP in the recanalized group at 3 h after thrombolysis was higher than that in the uncanalized group,and those in the recanalized group at 9,12 h after thrombolysis were lower than those in the uncanalized group(P<0.05);TAFI in the recanalized group at 1,3 h after thrombolysis were higher than those in the uncanalized group,and those in the recanalized group at 9,12 h after thrombolysis were lower than those in the uncanalized group(P<0.05);and the levels of PAI-1 in the recanalized group at 3,9 and 12 h after thrombolysis were higher than those in the uncanalized group(P<0.05).The area under the curve(AUC)value of H-FABP,TAFI and PAI-1 combined detection in predicting vascular recanalization in STEMI patients was higher than that of single detection(P<0.05).Conclusion:The combined detection of plasma H-FABP,TAFI and PAI-1 has high predictive value for vascular recanalization in patients with STEMI undergoing intravenous thrombolysis.关键词
ST段抬高型急性心肌梗死/静脉溶栓/血管再通/心型脂肪酸结合蛋白Key words
ST segment elevation acute myocardial infarction/Intravenous thrombolysis/Vascular recanalization/Heart-type fatty acid binding protein
