中国癌症防治杂志2024，Vol.16Issue(3)：321-326,6.DOI:10.3969/j.issn.1674-5671.2024.03.09
以眼部肿物为首发表现的鼻型结外NK/T细胞淋巴瘤的临床分析
Clinical analysis of extranodal NK/T-cell lymphoma,nasal type,manifesting with primary ocular lesions
摘要
Abstract
Objective To compare the differences in clinical characteristics,therapeutic effectiveness and prognosis between extranodal NK/T-cell lymphoma,nasal type(ENKTCL)manifesting with primary ocular lesions and ENKTCL with other primary lesions.Methods The clinical data of 266 newly diagnosed and untreated ENKTCL patients admitted to the Department of Hematology,Beijing Tongren Hospital Affiliated to Capital Medical University from May 2009 to February 2021 were retrospectively analyzed.Combined with the follow-up results,the clinical characteristics,therapeutic remission rate and survival between the two groups were compared.Results Among the 266 patients with ENKTCL,26 cases manifested with primary ocular lesions,with eyelid swelling being the most common clinical manifestation.Compared with the non-ocular ENKTCL groups,the ocular ENKTCL groups had a higher proportion of stage Ⅲ/Ⅳ patients(23.8％vs 42.3％,P=0.0394)and a higher proportion of patients with elevated LDH(27.1％vs 46.2％,P=0.0417).In terms of prognosis,the KPI score≥3 scores of the ocular ENKTCL group was higher than that of the non-ocular ENKTCL groups(46.2％vs 21.3％,P=0.0046).The proportion of patients in the ocular ENKTCL group with PINK score at high risk was higher than that in the non-ocular ENKTCL group(38.5％vs 19.2％,P=0.0219).In terms of therapeutic effectiveness,there was no significant difference in the choice of treatment regimen between the two groups.The proportion of patients assessed as progressive disease in the ocular ENKTCL group was higher than that in the non-ocular ENKTCL groups(46.2％vs 22.9％,P=0.0090).In terms of survival,12(46.2％)patients died in the ocular ENKTCL group and 56(23.3％)patients died in the non-ocular ENKTCL group.There was no significant difference in the 3-year and 5-year PFS rates between the two groups;while the 3-year OS rates in the ocular and non-ocular ENKTCL groups were 69.2％and 76.7％,respectively;the 5-year OS rates were 58.6％and 72.2％,respectively,with statistically significant differences(P=0.0321).Conclusions ENKTCL manifesting with primary ocular lesions as the initial clinical manifestation demonstrates distinct features,including high tumor burden,accelerated disease progression,and limited response to therapeutic interventions.The prompt utilization of imaging examinations and tissue biopsy is crucial for precise diagnosis.关键词
鼻型结外NK/T细胞淋巴瘤/眼部起病/临床特征/疗效/预后Key words
Extranodal NK/T-cell lymphoma,nasal type/Manifesting with primary ocular lesions/Clinical characteristics/Therapeutic effectiveness/Prognosis分类
医药卫生引用本文复制引用
杨磊,曾立洁,陶建华,姚娜,丛佳,杨晶,王赫男,魏立强,王亮..以眼部肿物为首发表现的鼻型结外NK/T细胞淋巴瘤的临床分析[J].中国癌症防治杂志,2024,16(3):321-326,6.基金项目
国家自然科学基金项目(82170181 （）
82370188) （）
北京市自然科学基金项目(7222027) （7222027）
国家重点研发计划项目(2022YFF1502000) （2022YFF1502000）
