美国国家综合癌症网络《胃癌临床实践指南》(2024年第一版)更新要点解读OA北大核心CSTPCD

On March 7,2024,the National Comprehensive Cancer Network issued the first edition of the 2024 clinical practice guidelines for gastric cancer,which updated endoscopic therapy for early gastric cancer,next generation sequencing,diagnosis and treatment of peritoneal metastases,principles of systemic therapy,and nutritional deficiency surveillance.Especially for the hot issues of intraperitoneal chemotherapy or hyperthermic intraperitoneal chemotherapy for advanced gastric cancer with peritoneal metastasis in recent years,the guidelines elaborated in detail the indications,multidisciplinary treatment mode,and evaluation of efficacy.In an era of continuous knowledge and information updates,the NCCN guidelines are regularly revised to adapt to new challenges.New molecular techniques are increasingly prominent in the precision diagnosis and treatment of gastric cancer.Minimally invasive treatments,including endoscopic therapy,laparoscopic surgery,and robotic surgery,have been incorporated into the guidelines as more evidence-based medicine and clinical practice experiences accumulate.This reflects surgeons'relentless pursuit of improved long-term survival and quality of life for patients.Likewise,novel anti-tumor drugs,such as immune checkpoint inhibitors,targeted therapy drugs,and antibody-drug conjugates,are gaining importance in the systemic treatment of gastric cancer,providing patients with more therapeutic options.In the future,adhering to a"patient-centered"treatment philosophy and actively promoting multidisciplinary collaboration and comprehensive management will be essential to achieving the ultimate goals of all treatment guidelines.