硝苯地平联合拉贝洛尔对子痫前期患者胎盘血流灌注的影响OA

Objective:To investigate the disease control effect and safety of Nifedipine combined with Labetalol of patients with preeclampsia,and observe the influence for and placental blood perfusion.Method:A total of 82 patients with preeclampsia in Jingmen Traditional Chinese Medicine Hospital from January 2018 to August 2023 were divided into two groups by the random number table,with 41 cases in each group.The control group were treated with Labetalol,the observation group were treated with Nifedipine combined with Labetalol.Then the treatment effect,adverse reaction rates,vasoconstriction and vasodilation factors[endothelin-1(ET-1),nitric oxide(NO)]and placental blood perfusion indexes[vascularization index(VI),flow index(FI)and vascularization-flow index(VFI)]before and after the treatment of two groups were compared.Result:The total effective rate of observation group was significantly higher than that of control group,the difference was statistically significant(P<0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no significant differences in vasoconstriction and relaxation factor and placental blood perfusion index between the two groups(P>0.05);after 15 and 30 days of treatment,the ET-1 of the two groups were lower than those before treatment,and the ET-1 of the observation group were lower than those of the control group,placental blood perfusion indexes in the two groups were higher than those before treatment,and placental blood perfusion indexes in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of Nifedipine combined with Labetalol in patients with preeclampsia is better,and it can significantly improve the placental blood perfusion of patients.