中国实用外科杂志2024，Vol.44Issue(6)：619-624,6.DOI:10.19538/j.cjps.issn1005-2208.2024.06.04
有关远处转移性分化型甲状腺癌放射性碘治疗的意义
Iodine-131 therapy for distant metastases of differentiat-ed thyroid carcinoma
摘要
Abstract
Differentiated thyroid carcinoma(DTC)is a common type of thyroid cancer,including papillary thyroid carcinoma(PTC),follicular thyroid carcinoma(FTC),and oncocytic thyroid carcinoma(OTC).Although most patients with DTC have a favorable prognosis following surgery,radioactive iodine therapy(RAIT),and TSH suppression therapy,a subset of patients develop distant metastatic differentiated thyroid carcinoma(DM-DTC),with the lungs and bones being the most common sites of metastasis.RAIT is the first-line postoperative treatment for DM-DTC and can effectively reduce recurrence and mortality risks.The RAIT treatment plan for DM-DTC should be individualized based on the iodine uptake characteristics of the lesions.Research indicates that RAIT has a high complete remission rate for lung micro-metastases,while for bone metastases,although the cure rate is low,it significantly improves prognosis.Additionally,preparatory work before RAIT,such as elevated TSH levels and a low-iodine diet,significantly impacts treatment outcomes.The pre-assessment of iodine uptake capability(e.g.,Dx-WBS)and the detection of molecular characteristics(e.g.,BRAFV600E and TERT promoter mutations)help predict RAIT efficacy and the risk of RAIR-DTC.For patients who do not uptake iodine or have poor treatment responses,other local treatments or novel molecular-targeted drugs should be considered to improve survival rates and quality of life.Overall,RAIT plays a crucial role in of treating DM-DTC,but comprehensive decision-making and dynamic adjustments based on individual conditions are necessary.关键词
分化型甲状腺癌/远处转移/放射性碘治疗Key words
differentiated thyroid carcinoma/distant metastat-ic/radioactive iodine-131 therapy分类
医药卫生引用本文复制引用
林岩松,李若尘..有关远处转移性分化型甲状腺癌放射性碘治疗的意义[J].中国实用外科杂志,2024,44(6):619-624,6.基金项目
北京协和医院中央高水平医院临床科研专项基金项目(No.2022-PUMCH-B072) （No.2022-PUMCH-B072）
