中国药业2024，Vol.33Issue(13)：121-128,8.DOI:10.3969/j.issn.1006-4931.2024.13.029
芪胶升白胶囊防治恶性肿瘤放化疗后骨髓抑制临床疗效Meta分析
Clinical Efficacy of Qijiao Shengbai Capsules in the Prevention and Treatment of Malignant Tumors with Myelosuppression After Chemoradiotherapy:A Meta-Analysis
摘要
Abstract
Objective To systematically evaluate the clinical efficacy of Qijiao Shengbai Capsules in the prevention and treatment of malignant tumor with myelosuppression after chemoradiotherapy,and to provide a reference for clinical medication.Methods Database such as CNKI,WanFang,VIP,SinoMed,PubMed,Web of Science and The Cochrane Library were searched from their inception of the database to April 22,2023 to collect the randomized controlled trials(RCT)related to Qijiao Shengbai Capsules in the prevention and treatment of malignant tumors with myelosuppression after chemoradiotherapy.The modified Jadad Scale was used to evaluate the quality of the included literature,and Meta-analysis was performed by the RevMan 5.4 software.Results A total of 25 RCTs involving 2 754 patients were included,including 1 466 cases in the experimental group and 1 288 cases in the control group.Meta-analysis results showed that the overall myelosuppression rate[OR=0.27,95% CI(0.21,0.35),P<0.000 01],grade Ⅲ-Ⅳ myelosuppression rate[OR=0.23,95% CI(0.16,0.34),P<0.000 01],leukocytes[MD=1.18,95% CI(0.98,1.38),P<0.000 01],platelets[MD=14.06,95% CI(12.95,15.16),P<0.000 01],hemoglobin[MD=0.98,95% CI(0.87,1.09),P<0.000 01],KPS score improvement rate[OR=2.65,95% CI(1.90,3.70),P<0.000 01],KPS score[MD=6.13,95% CI(4.48,7.79),P<0.000 01]were significantly better than those in the control group.Conclusion Qijiao Shengbai Capsules can effectively reduce the overall myelosuppression rate and grade Ⅲ-Ⅳ myelosuppression rate of malignant tumor patients after chemoradiotherapy,increase KPS score and levels of leukocytes,hemoglobin,and platelets,so as to improve myelosuppression.关键词
芪胶升白胶囊/恶性肿瘤/随机对照试验/骨髓抑制/临床疗效/Meta分析Key words
Qijiao Shengbai Capsules/malignant tumor/randomized controlled trials/myelosuppression/clinical efficacy/Meta-analysis分类
医药卫生引用本文复制引用
刘莎莎,王阿娇,孙晓东,李媛媛,陈佳佩..芪胶升白胶囊防治恶性肿瘤放化疗后骨髓抑制临床疗效Meta分析[J].中国药业,2024,33(13):121-128,8.基金项目
河北省廊坊市科学技术研究与发展计划项目[2017013048]. （）
