中国药业2024，Vol.33Issue(13)：后插1-后插4,4.DOI:10.3969/j.issn.1006-4931.2024.13.030
临床药师参与1例万古霉素致药物性肝损伤及药物热临床实践
Clinical Pharmacist' Clinical Practice in a Case of Vancomycin-Induced Drug-Induced Liver Injury and Drug Fever
摘要
Abstract
Objective To promote the rational use of vancomycin in the clinic.Methods A clinical pharmacist participated in the treatment process of a case of drug-induced liver injury(DILI)and drug fever caused by vancomycin,and provided pharmaceutical care for the patient.Based on literature and changes in the patient's daily examination indicators,the clues leading to DILI and drug fever were discovered on time,and the drugs were stopped and treated accordingly.Results The drugs causing DILI was identified through the RUCAM score,and the drugs causing drug fever was found through exclusion diagnosis.Literature review and patient's examination indicators were used to infer that the vancomycin-induced DILI and drug fever occurred simultaneously,which was related to hypersensitivity reactions in humoral immunity.Conclusion When using vancomycin in the clinic,in addition to paying attention to adverse reactions of renal function in patients,attention should also be paid to changes in liver function and body temperature.If liver function injury or high body temperature occurs,it is necessary to be alert to adverse drug reactions induced by vancomycin.关键词
药物性肝损伤/药物热/万古霉素/超敏反应/临床药师Key words
drug-induced liver injury/drug fever/vancomycin/hypersensitivity reaction/clinical pharmacist分类
医药卫生引用本文复制引用
张井明,张中伟,陈燕..临床药师参与1例万古霉素致药物性肝损伤及药物热临床实践[J].中国药业,2024,33(13):后插1-后插4,4.基金项目
上海交通大学医学院"临床药学创新研究院"专项建设项目[CXYJY2019MS005]. （）
