摘要
Abstract
microRNA(miRNA)are a type of non coding RNA that play an important role in regulating gene expression,with an average length of 22 nucleotides.They are widely expressed in different species and play biological functions in receptor cells,regulating their activity,and thus acting as intercellular signaling molecules.This feature is crucial in signal transduction between pancreatic acinar and ductal cells,immune cells,and pancreatic stellate cells,and plays an important role in the occurrence and development of acute and chronic pancreatitis.A single miRNA can regulate the expression of multiple targets,providing an effective mechanism for therapeutic intervention.In addition,miRNA regulates the expression of cytokines and chemokines,as well as cell proliferation,tissue remodeling,and migration,thereby regulating the development of pancreatic fibrosis.A total of 40 and 13 differentially expressed miRNA were screened in the pancreas and pancreatitis.At present,there are many studies on the expression and role of miRNA in pancreatitis,and miRNA has great potential as a serum or tissue specific biomarker for clinical application in pancreatitis.关键词
微小RNA/急性胰腺炎/慢性胰腺炎/炎症/自噬Key words
miRNA/Acute pancreatitis/Chronic pancreatitis/Inflammatory/Autophagy
