中国医学前沿杂志（电子版）2024，Vol.16Issue(6)：18-23,6.DOI:10.12037/YXQY.2024.06-04
表观遗传学在慢性阻塞性肺疾病中的作用和机制研究进展
Research progress on the role and mechanism of epigenetics in chronic obstructive pulmonary disease
摘要
Abstract
Chronic obstructive pulmonary disease(COPD)is a disease characterized by persistent airflow limitation due to abnormal of airway or alveolar structures.COPD is primarily caused by cigarette smoking and environmental exposure.A series of complex,cumulative,and dynamic gene-environment interactions which eventually leads to the onset of COPD.Epigenetics is a key integrator of environmental exposure and genetic inheritance,and now has become an important area of COPD research.This article reviews the role and mechanism of epigenetic modification in COPD,aiming to gain further understanding of the pathogenesis of COPD.关键词
表观遗传学/慢性阻塞性肺疾病/脱氧核糖核酸甲基化/组蛋白修饰/非编码核糖核酸Key words
Epigenetics/Chronic obstructive pulmonary disease/DNA methylation/Histone modification/Noncoding RNA引用本文复制引用
林思含,贾国华..表观遗传学在慢性阻塞性肺疾病中的作用和机制研究进展[J].中国医学前沿杂志（电子版）,2024,16(6):18-23,6.基金项目
Natural Science Foundation of Hubei Province(2023AFB218) （2023AFB218）
the Fundamental Research Funds for the Central Universities(2042022kf1109)湖北省自然科学基金(2023AFB218) （2042022kf1109）
中央高校基本科研业务费专项资金资助(2042022kf1109) （2042022kf1109）
