表观遗传学在慢性阻塞性肺疾病中的作用和机制研究进展OA北大核心CSTPCD
Research progress on the role and mechanism of epigenetics in chronic obstructive pulmonary disease
慢性阻塞性肺疾病(简称慢阻肺)是一种以气道或肺泡结构异常导致的持续性气流受限为特征的疾病.慢阻肺主要由香烟烟雾和环境暴露等导致,其发病机制复杂,是一系列复杂的、累积的、动态的基因-环境相互作用的终产物.表观遗传学是整合环境暴露和基因遗传的关键,近年来,随着研究的进展,人们关注到表观遗传学在慢阻肺发生发展中发挥重要的作用.本文就表观遗传学在慢阻肺发生发展中的作用和机制作一综述,以便对慢阻肺的发病机制作更深一步了解.
Chronic obstructive pulmonary disease(COPD)is a disease characterized by persistent airflow limitation due to abnormal of airway or alveolar structures.COPD is primarily caused by cigarette smoking and environmental exposure.A series of complex,cumulative,and dynamic gene-environment interactions which eventually leads to the onset of COPD.Epigenetics is a key integrator of environmental exposure and genetic inheritance,and now has become an important area of COPD research.This article reviews the role and mechanism of epigenetic modification in COPD,aiming to gain further understanding of the pathogenesis of COPD.
林思含;贾国华
武汉大学人民医院 肿瘤中心,湖北 武汉 430060
表观遗传学慢性阻塞性肺疾病脱氧核糖核酸甲基化组蛋白修饰非编码核糖核酸
EpigeneticsChronic obstructive pulmonary diseaseDNA methylationHistone modificationNoncoding RNA
《中国医学前沿杂志（电子版）》 2024 (006)
18-23 / 6
Natural Science Foundation of Hubei Province(2023AFB218);the Fundamental Research Funds for the Central Universities(2042022kf1109)湖北省自然科学基金(2023AFB218);中央高校基本科研业务费专项资金资助(2042022kf1109)
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