关节腔靶向注射臭氧联合中药外敷治疗早期类风湿关节炎膝关节病变的临床研究OA
Clinical Study of Targeted Injection of Ozone in Joint Cavity Combined with External Application of Traditional Chinese Medicine in the Treatment of Knee Lesions in Early Rheumatoid Arthritis
目的:探究关节腔靶向注射臭氧联合中药外敷治疗早期类风湿关节炎膝关节病变的临床效果.方法:回顾性选取九江市第一人民医院 2022 年 6 月—2023 年 9 月收治的 80 例早期类风湿关节炎膝关节病变患者,根据治疗方案将其分为联合组(n=47)和对照组(n=33),对照组采用临床常规治疗方案,即采用曲安奈德进行关节腔注射治疗,联合组采用关节腔靶向注射臭氧联合中药外敷治疗.均治疗 3 周.比较两组疗效;比较两组治疗前后的C反应蛋白(CRP)、抗环瓜氨酸多肽抗体(ACCP)、类风湿因子(RF)和甘露聚糖结合凝集素(MBL)水平;比较两组治疗前后的视觉模拟评分法(VAS)评分及关节超声评估情况.结果:联合组总有效率为 93.62%,高于对照组的 72.73%,差异有统计学意义(P<0.05).治疗后,两组血清RF、CRP、ACCP水平均低于治疗前,且联合组均低于对照组;两组血清MBL水平均高于治疗前,且联合组高于对照组,差异均有统计学意义(P<0.05).治疗后,两组髌上囊积液深度、髌上囊滑膜厚度、VAS评分均低于治疗前,且联合组均低于对照组,差异均有统计学意义(P<0.05).结论:关节腔靶向注射臭氧联合中药外敷治疗早期类风湿关节炎膝关节病变的效果较好,可以显著改善患者的血清学指标和疼痛程度,并减轻膝关节病变.
Objective:To explore the clinical effect of targeted injection of ozone in joint cavity combined with external application of traditional Chinese medicine in the treatment of early rheumatoid arthritis knee lesions.Method:A total of 80 patients with early rheumatoid arthritis knee lesions admitted to Jiujiang NO.1 People's Hospital from June 2022 to September 2023 were retrospectively selected and divided into a combination group(n=47)and a control group(n=33)according to the treatment plan.The control group was treated with routine clinical treatment,that was,Triamcinolone Acetonide was used for intra-articular injection.The combined group was treated with joint cavity targeted injection of ozone combined with external application of traditional Chinese medicine.All patients were treated for 3 weeks.The efficacy of the two groups was compared.The levels of C reactive protein(CRP),anti-cyclic citrulline polypeptide antibody(ACCP),rheumatoid factor(RF)and mannan-binding lectin(MBL)before and after treatment were compared between the two groups.Visual analogue scale(VAS)score and joint ultrasound evaluation were compared between the two groups before and after treatment.Result:The total effective rate of the combined group was 93.62%,which was higher than 72.73%of the control group,the difference was statistically significant(P<0.05).After treatment,the serum RF,CRP and ACCP levels in two groups were lower than before treatment,and those in the combined group were lower than those of the control group,the serum MBL levels in two groups were higher than before treatment,and that in the combined group was higher than that in the control group,with statistical significance(P<0.05).After treatment,the effusion depth of suprapatellar bursae,synovial thickness of suprapatellar bursae and VAS score of two groups were lower than before treatment,and those of the combined group were lower than those of the control group,with statistical significance(P<0.05).Conclusion:Joint cavity targeted injection of ozone combined with external application of traditional Chinese medicine in the treatment of early rheumatoid arthritis knee lesions is highly effective,can significantly improve the serological indicators and pain degree of patients,and alleviate the knee lesions.
张徐明;刘炬;姬森国;吴頔;刘芳
九江市第一人民医院风湿免疫科 江西 九江 332000
关节腔靶向注射臭氧中药外敷早期类风湿关节炎膝关节病变
Joint cavity targeted injection of ozoneExternal application of traditional Chinese medicineEarly rheumatoid arthritisKnee disease
《中国医学创新》 2024 (016)
49-53 / 5
江西省中医药管理局科技计划项目(2023B0809)
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