中国合理用药探索2024，Vol.21Issue(6)：76-81,6.DOI:10.3969/j.issn.2096-3327.2024.06.012
阿司匹林联合拉贝洛尔对妊娠期高血压患者血压、炎症因子、沉默信息调节因子的影响
Effects of Aspirin Combined with Labetalol on Blood Pressure,Inflammatory Factors and Silent Information Regulators in Patients with Hypertension in Pregnancy
摘要
Abstract
Objective:To investigate the effects of 75mg/d aspirin combined with labetalol on blood pressure,inflammatory factors and silent information regulators(SIRTs)in patients with hypertension in pregnancy.Methods:A total of 92 hypertension in pregnancy patients treated in a hospital from March 2022 to March 2023 were selected and divided into the control group and observation group by random number table method,with 46 patients in each group.Both groups were given conventional treatment such as sedation,volume expansion and limiting salt intake.The control group was additionally treated with labetalol hydrochloride tablets,and the observation group was treated with aspirin enteric-coated tablets in addition to the treatment given in the control group.Blood pressures(systolic and diastolic blood pressures),inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)],SIRTs[silent information regulator 1(SIRT1),silent information regulator 3(SIRT3)],adverse pregnancy outcomes and adverse reactions were compared between the two groups.Results:After treatment,the diastolic and systolic blood pressures were decreased in both groups(P<0.05),and were lower in the observation group as compared with the control group(P<0.05).The serum levels of IL-6,TNF-α,IL-8 were decreased in both groups(P<0.05),and were lower in the observation group as compared with the control group(P<0.05).The serum levels of SIRT1 and SIRT3 were increased in both groups(P<0.05),and were higher in the observation group as compared with the control group(P<0.05).The incidence of adverse pregnancy outcomes in the observation group(21.74%)was lower than that in the control group(52.17%,P<0.05).No statistically significant difference in the occurrence of adverse reactions was observed between the two groups(P>0.05).Conclusion:75mg/d aspirin combined with labetalol in the treatment of hypertension in pregnancy can effectively control the blood pressure,reduce the levels of inflammatory factors,increase the levels of SIRT1 and SIRT3,and effectively reduce the incidence of adverse pregnancy outcomes with low incidence of adverse reactions.关键词
阿司匹林/拉贝洛尔/妊娠期高血压/炎症因子/沉默信息调节因子Key words
aspirin/labetalol/hypertension in pregnancy/inflammatory factors/silent information regulators分类
医药卫生引用本文复制引用
李梦竹,李瓅,周亚丹..阿司匹林联合拉贝洛尔对妊娠期高血压患者血压、炎症因子、沉默信息调节因子的影响[J].中国合理用药探索,2024,21(6):76-81,6.基金项目
河南省医学科技攻关计划项目(LHGJ20210239) （LHGJ20210239）
