Abstract
Objective:To investigate the effect of Sangbaipi Decoction and Naloxone Hydrochloride in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with respiratory failure.Method:A total of 60 patients with AECOPD with respiratory failure admitted to Bijie Traditional Chinese Medicine Hospital from February 2021 to January 2024 were divided into two groups according to the random number table method,with 30 cases in each group.The control group was treated with Naloxone Hydrochloride Injection,and the observation group was treated with Sangbaipi Decoction for two weeks.The clinical effects,lung function index,blood gas index,inflammation index,TCM syndrome score and incidence of adverse effects of the two groups were compared.Result:The total effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).After treatment,forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),the percentage of forced expiratory volume in 1 second to forced vital capacity(FEV1/FVC%)were(3.12±0.48)L,(2.24±0.41)L,(71.78±5.71)%,which were higher than(2.75±0.43)L,(1.89±0.35)L,(68.72±5.41)%in the control group,the differences were statistically significant(P<0.05).After treatment,the partial pressure of carbon dioxide(PaCO2)was(41.25±4.53)mmHg in the observation group,which was lower than(46.87±4.75)mmHg in the control group,and the partial pressure of blood oxygen(PaO2)was(84.59±6.53)mmHg,which was higher than(76.72±6.19)mmHg in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6),procalcitonin(PCT),and hypersensitive C reactive protein(hs-CRP)in the observation group were(12.32±1.25)pg/mL,(0.43±0.11)μg/L,and(8.62±1.13)ng/mL,which were lower than(15.07±1.42)pg/mL,(0.54±0.13)μg/L,(10.57±1.25)mg/L,the differences were statistically significant(P<0.05).After treatment,the TCM syndrome scores of cough,yellow phlegm,asthma breath,chest tightness in the observation group were(0.89±0.12),(1.02±0.15),(0.92±0.14),(0.78±0.11)points,which were lower than(1.12±0.19),(1.29±0.18),(1.22±0.17)and(0.93±0.14)points in the control group,the differences were statistically significant(P<0.05).There was no significant difference in rate of adverse reactions between the two groups(P>0.05).Conclusion:The combination of Sangbaipi Decoction and Naloxone Hydrochloride can accelerate the resolution of lung inflammation in AECOPD patients with respiratory failure,correct blood gas index,promote lung function recovery,and be safe and reliable.关键词
慢性阻塞性肺疾病/呼吸衰竭/桑白皮汤/盐酸纳洛酮/肺功能Key words
Chronic obstructive pulmonary disease/Respiratory failure/Sangbaipi Decoction/Naloxone Hydrochloride/Lung function
